The effect of the type of intraperitoneally implanted prosthetic mesh on the systemic inflammatory response

Hernia : the Journal of Hernias and Abdominal Wall Surgery
G ChatzimavroudisKonstantinos Atmatzidis

Abstract

The purpose of this study was to determine any differences in the systemic inflammatory response after the intraperitoneal implantation of three different types of polypropylene mesh. Thirty-two male New Zealand rabbits underwent a 6-cm midline incision and opening of the peritoneal cavity. The animals were randomly divided into four groups. In groups A, B, and C, there was an intraperitoneal placement of polypropylene mesh, titanium-coated polypropylene mesh, and composite polypropylene/e-PTFE mesh, respectively. Group D received a sham operation. Blood was sampled preoperatively and at 6, 24, 48, and 168 h postoperatively to measure white blood cell count (WBC), tumor necrosis factor-alpha (TNF-alpha), and malondialdehyde (MDA). Statistically significant elevations of WBC, TNF-alpha and MDA were observed in all four groups at 6, 24, and 48 h postoperatively (P<0.05). There were no statistically significant differences in WBC, TNF-alpha, and MDA between groups A, B, and C at any time interval. However, a statistically significant elevation of WBC (P<0.05) and TNF-alpha (P<0.05) was observed between each of the groups with mesh implantation and group D at 24 h postoperatively. Intraperitoneal mesh implantation induces mild syst...Continue Reading

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Citations

Nov 21, 2013·Hernia : the Journal of Hernias and Abdominal Wall Surgery·F Köckerling, C Schug-Pass
Dec 9, 2009·American Journal of Surgery·Bhavin C ShahDmitry Oleynikov
Jun 11, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Alessandro PrudenteCassio Luis Zanettini Riccetto
Oct 4, 2012·Acta Cirúrgica Brasileira·Patrick dos Santos Barros dos ReisAlberto Schanaider
Feb 8, 2018·Immunological Investigations·Paraskevi MatsotaEvangelos J Giamarellos-Bourboulis

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