Apr 1, 1975

The effect of therapeutic gentamycin doses on the enzyme secretion in urine

Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete
U BurchardtC A Gründig

Abstract

8 patients with chronic pyelonephritis were given gentamycin intramuscularly injected in individual dosage during 8-10 days. Here the behaviour of the excretion of protein, alanine aminopeptidase alkaline phosphatase, alpha-glucosidase, gamma-glutamyl transpeptidase and lysozyme with the urine was tested. With the exception of the lysozymuria, which increased only in patients with chronic renal insufficiency, regularly a hyperenzymuria developed. Most distinctly the excretion of the alanine aminopeptidase increased. After initial decrease the excretion of total protein transiently increased after completion of the gentamycin therapy. All the deviations were reversible. From the increased excretion of enzymes may not be concluded to a nephrotoxicity of gentamycin.

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Mentioned in this Paper

Urine
Enzymes, antithrombotic
Gentamicins
Chronic Kidney Insufficiency
Gentacycol
Gamma-glutamyl transferase
Lysozyme Test
Alkaline Phosphatase Measurement
Proteinuria
Renal Tubule Structure

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