The effect of thiamine pyrophosphate on ethambutol-induced ocular toxicity

Cutaneous and Ocular Toxicology
Emine CiniciHalis Suleyman

Abstract

Ethambutol-induced retinal oxidative damage in patients with tuberculosis is still not being adequately treated. The protective effect of thiamine pyrophosphate against oxidative damage in some tissues has been reported, but no information on the protective effects of thiamine pyrophosphate against ethambutol-induced oxidative retinal damage has been found in the medical literature. The objective is to investigate whether thiamine pyrophosphate has a protective effect against oxidative retinal damage in rats induced by ethambutol. Experimental animals divided into four groups (n = 10): the healthy group (HG), the ethambutol control group (EMB), thiamine + ethambutol group (Thi-EMB) and thiamine pyrophosphate + ethambutol group (TPP-EMB). The rats in the TPP-EMB and Thi-EMB groups were administered thiamine pyrophosphate and thiamine, respectively, at doses of 20 mg/kg intraperitoneally. Distilled water was administered intraperitoneally to the HG and the EMB groups as a solvent in the same volumes. One hour after drug injection, 30 mg/kg ethambutol was administered via an oral gavage to the TPP-EMB, Thi-EMB and EMB groups. This procedure was repeated once a day for 90 days. At the end of this period, all rats were euthanized un...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Feb 14, 1991·Biochemical and Biophysical Research Communications·J P BattioniD Mansuy
Apr 20, 1966·Annals of the New York Academy of Sciences·I D Bobrowitz
Jan 1, 1993·The Annals of Pharmacotherapy·K L Alvarez, L C Krop
Aug 2, 2000·The American Journal of Clinical Nutrition·P M Clarkson, H S Thompson
Jun 25, 2003·Toxicology·Maria L Urso, Priscilla M Clarkson
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcus S CookeJoseph Lunec
Jan 27, 2004·American Journal of Respiratory and Critical Care Medicine·Edward D ChanMichael D Iseman
Aug 25, 2004·Archives of Biochemistry and Biophysics·Kyung-Jin YeumGiancarlo Aldini
Feb 18, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hülya BayirPatrick M Kochanek
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Aug 4, 2007·Congestive Heart Failure·Domenic A Sica
Sep 1, 2007·Seminars in Ophthalmology·Setareh VistamehrRon A Adelman
Jan 29, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Fu YuDecheng Bai
Apr 7, 2010·Chemico-biological Interactions·Beyzagul PolatHamit Hakan Alp
Nov 24, 2011·Progress in Retinal and Eye Research·Christian Caprara, Christian Grimm
Sep 8, 2012·Investigative Ophthalmology & Visual Science·Junzo KinoshitaMitsuya Yasuda
Jan 29, 2013·Cutaneous and Ocular Toxicology·Alparslan ŞahinOsman Gökalp
Sep 5, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Peter F KadorKaren Blessing
Oct 16, 2014·Journal of Cardiovascular Pharmacology and Therapeutics·B PolatF Akcay
Feb 1, 2013·The Eurasian Journal of Medicine·Abdullah KisaogluHalis Suleyman
Jan 28, 2015·Lung India : Official Organ of Indian Chest Society·Pragati GargAshwini Kumar Mishra

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