Feb 1, 1986

The effect of thioacetamide on rat liver plasma membrane enzymes and its potentiation by fasting

Toxicology
V NikolaevE Ivanov

Abstract

Thioacetamide, given intraperitoneally (1.4 mmol/kg body mass) to male Wistar rats 24 h before sacrifice promoted a marked elevation of serum aminotransferases, loss of microsomal cytochrome P-450 content and a significant reduction (about 50%) of the liver plasma membrane enzymatic activities (5'-nucleotidase; K+, Na+- and Mg2+-adenosine triphosphatases; and gamma-glutamyl transferase). Previous starvation for 48 h, immediately prior to thioacetamide administration, strongly potentiated the effects of thioacetamide on the serum, microsomal and liver plasma membrane parameters, while fasting itself did not affect them. The liver plasma membrane damage may be one of the reasons for the cell death in thioacetamide-intoxicated rat livers.

Mentioned in this Paper

Necrosis
Enzymes, antithrombotic
Adenosine Triphosphatases
Thioacetamide
Gamma-glutamyl transferase
August Rats
Cytochrome P450
Acetamides
Cytochrome P-450 Oxygenase
Microsomes, Liver

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