The effect of thymosin α1 on mortality of critical COVID-19 patients: A multicenter retrospective study.

International Immunopharmacology
Qin SunYi Yang

Abstract

Thymosin α1 therapy was commonly used in patients with coronavirus disease 2019 (COVID-19), while its impact on outcomes and which patients could benefit from thymosin α1 therapy were uncertain. Patients with COVID-19 from 19 designated hospitals between January 1 to February 29, 2020 were included, and the main exposure of interest was administration of thymosin α1. The primary outcome was 28-day mortality. Propensity score matching (PSM) was used to account for baseline confounders, cluster analysis and Cox proportional hazard model was used to account for subgroup analysis. A total of 771 patients were included, and 327/771 (42.4%) patients received thymosin α1 therapy. The 28-day mortality in thymosin group was significantly lower than that in control group (41.3% vs. 60.6%, p < 0.001). After PSM 522 patients were included in analysis and the 28-day mortality in thymosin α1 group and control group were 51.0% and 52.9% respectively, with no significant difference. In subgroup analyses, the association between thymosin α1 therapy and 28-day mortality appeared to be stronger among male patients (HR 0.673, 95% CI 0.454-0.998; p = 0.049). There were no benefits of thymosin α1 in 28-day mortality in other subgroups. There were tw...Continue Reading

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Citations

Apr 27, 2021·The American Journal of Emergency Medicine·Tao LiuJingjing Zhang
Jul 9, 2021·Therapeutics and Clinical Risk Management·Hong Peng LiQing Yun Li
Aug 20, 2021·Frontiers in Immunology·Jiao LiuDechang Chen

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