PMID: 11908467Mar 23, 2002Paper

The effect of tibolone on the lipoprotein profile of postmenopausal women with type III hyperlipoproteinemia

Journal of Internal Medicine
F de BeerJ A Gevers Leuven

Abstract

To investigate the short-term effect of treatment with tibolone on plasma lipid and lipoprotein levels in postmenopausal women with type III hyperlipoproteinemia (HLP). Patients were randomized to receive, in a double-blind cross-over fashion, a fixed dose of tibolone, 2.5 mg once daily or placebo for 8 weeks. The two treatment periods were separated by a wash-out period of 6 weeks. At each visit body weight and blood pressure were determined. Before and after each treatment period, fasting venous blood samples were obtained from the patients for biochemical measurements. The Leiden University Medical Center. Postmenopausal women with type III HLP (aged < or = 65 years) were recruited from the Lipid Clinics of the Leiden University Medical Center, the Amsterdam Medical Center, the Utrecht Medical Center and the University Hospital Rotterdam. Five out of 25 women with type III HLP were eligible to be included in the study. Four of the five included patients completed the study according to the protocol. One patient was excluded from blinded therapy because total cholesterol levels increased above 20 mmol L(-1). A significant reduction of plasma triglyceride, total cholesterol, VLDL cholesterol and VLDL triglyceride levels. Plasm...Continue Reading

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Citations

May 6, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John E Morley, H Mitchell Perry
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