The effect of timing of intrathecal fibrinolytic therapy on cerebral vasospasm in a primate model of subarachnoid hemorrhage

Neurosurgery
J M FindlayR Baughman

Abstract

The effect of intrathecal tissue plasminogen activator administered at times from 0 to 72 hours after subarachnoid hemorrhage on the development of cerebral vasospasm in primates was examined. Thirty monkeys were randomly assigned into one of five equal groups: a control group that underwent subarachnoid hemorrhage alone, and 0-, 24-, 48-, and 72-hour treatment groups that received 0.75 mg of tissue plasminogen activator at those times after baseline cerebral angiography and subarachnoid hemorrhage on the right side. Seven days later angiography was repeated and the animals were killed. One animal in the 72-hour group developed a delayed ischemic deficit on Day 7 after subarachnoid hemorrhage. In the control and 72-hour groups significant vasospasm occurred in most of the major, right cerebral arteries (P less than 0.05), but no significant vasospasm developed in the 0-, 24-, and 48-hour groups. Although a large subarachnoid clot remained in the control animals, most clot had been dissolved in all treatment groups. Lysing of subarachnoid hematoma with intrathecal tissue plasminogen activator within 72 hours of subarachnoid hemorrhage is effective in preventing vasospasm in primates.

Citations

Feb 28, 2006·Neurosurgical Review·R Loch Macdonald
Aug 24, 2010·British Journal of Neurosurgery·Serge MarbacherNeil D Kitchen
Apr 27, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tommaso ZoerleR Loch Macdonald
Apr 1, 1994·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·N W Dorsch
Jan 1, 1997·Critical Care Clinics·D Jichici, J I Frank
Dec 14, 2006·Neurological Research·Gary L Gallia, Rafael J Tamargo
Jul 1, 1995·Journal of Neurosurgery·K KinugasaY Matsumoto
Sep 2, 2000·Journal of Neurosurgery·M StoodleyA Kowalczuk
Sep 1, 1996·Stroke; a Journal of Cerebral Circulation·C J KimL M Johns

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.