The effect of topically applied n-butylester of 2,4-dichlorophenoxyacetic acid on the immune response in mice

Journal of Applied Toxicology : JAT
B R Blakley, B H Schiefer

Abstract

Six-week-old female CD-1 mice were administered the n-butylester of 2,4-dichlorophenoxyacetic acid (2,4-D). The 2,4-D ester was applied dermally at dosages ranging from 0 to 500 mg/kg (2,4-D content) in the acute studies and 0 to 300 mg/kg in the 3 week subacute studies. Following acute exposure, antibody production against sheep red blood cells was suppressed at higher exposure levels. Evidence of clinical toxicity, myotonia and depression, and histopathological alterations in the central nervous system including perivascular edema and ganglial cell necrosis, was also seen in the mice. No alterations were observed in the T- and B-lymphocyte proliferative responses induced by concanavalin A, a T-lymphocyte mitogen, or Escherichia coli lipopolysaccharide, a B-lymphocyte mitogen. Subacute 2,4-D ester exposure which produced minimal clinical or pathological alterations, had no effect on antibody production, but did enhance the B- and T-lymphocyte proliferative responses. The immunosuppressive effects of acute 2,4-D ester exposure which were observed in this study, were unlikely a direct immunological alteration, but rather a secondary manifestation of the clinical syndrome. Since the subacute exposure levels may be more comparable...Continue Reading

References

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Citations

Sep 28, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mary Sue MartyLarry Hammond
Sep 1, 1996·Occupational and Environmental Medicine·A FaustiniF Forastiere
Mar 15, 2005·Journal of Toxicology and Environmental Health. Part a·Patricia de la RosaRosana Schafer
Aug 1, 1992·Journal of Applied Toxicology : JAT·B R BlakleyC G Rousseaux

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