The effect of Toxoplasma gondii infection in flunixin meglumine treated pregnant ewes as monitored by plasma levels of 15-ketodihydroprostaglandin F2 alpha, progesterone, oestrone sulphate and ultrasound scanning

Zentralblatt für Veterinärmedizin. Reihe A
S AiumlamaiL E Edqvist

Abstract

The aim of this study was to examine the endocrinological response (15-ketodihydro-PGF2 alpha, progesterone and oestrone sulphate) of pregnant ewes which were constantly treated with flunixin meglumine (FM) after infection with Toxoplasma gondii. Seven Swedish Peltsheep ewes were dosed orally with 2,000 T. gondii oocysts at 90.5 (82-94) days of pregnancy. The ewes were treated with FM, 1 mg/kg, intramuscularly twice a day, starting one day before infection until the end of the gestation period. Further three ewes were treated with FM alone during the corresponding time of pregnancy. Another four ewes were used as uninfected and untreated controls. All infected ewes developed antibodies to T. gondii and aborted, but the FM treated control group and the non-treated control group, which remained seronegative, delivered the lambs in the normal gestation range. No early abortions (less than 10 days after infection) were seen in the infected group. The endocrinological changes reflected the pathological changes in the uterus and foetuses. FM could neither completely inhibit prostaglandin release during abortion nor the physiological change of the hormone before parturition even though it depressed prostaglandin release before abortio...Continue Reading

References

Nov 1, 1978·The Journal of Clinical Endocrinology and Metabolism·K WrightJ R Preedy
Sep 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·K OdensvikH Kindahl
Aug 1, 1989·Zentralblatt für Veterinärmedizin. Reihe A·S Aiumlamai, G Fredriksson
Sep 1, 1989·The British Veterinary Journal·D BuxtonD A Blewett
Feb 1, 1986·Veterinary Parasitology·J P Dubey
Dec 31, 1986·The Science of the Total Environment·E HäsänenP Alhonen
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·H Rabinovitch-ChableM Rigaud

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Citations

Jul 27, 2002·Domestic Animal Endocrinology·H KindahlH Gustafsson
Apr 28, 2009·Veterinary Parasitology·J P Dubey
Oct 28, 2014·Frontiers in Microbiology·María de la Luz Galván-RamírezJudith Marcela Dueñas Jiménez

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