The Effect of Transcranial Direct Current Stimulation (tDCS) Electrode Size and Current Intensity on Motor Cortical Excitability: Evidence From Single and Repeated Sessions

Brain Stimulation
Kerrie-Anne HoColleen K Loo

Abstract

Current density is considered an important factor in determining the outcomes of tDCS, and is determined by the current intensity and electrode size. Previous studies examining the effect of these parameters on motor cortical excitability with small sample sizes reported mixed results. This study examined the effect of current intensity (1 mA, 2 mA) and electrode size (16 cm(2), 35 cm(2)) on motor cortical excitability over single and repeated tDCS sessions. Data from seven studies in 89 healthy participants were pooled for analysis. Single-session data were analyzed using mixed effects models and repeated-session data were analyzed using mixed design analyses of variance. Computational modeling was used to examine the electric field generated. The magnitude of increases in excitability after anodal tDCS was modest. For single-session tDCS, the 35 cm(2) electrodes produced greater increases in cortical excitability compared to the 16 cm(2) electrodes. There were no differences in the magnitude of cortical excitation produced by 1 mA and 2 mA tDCS. The repeated-sessions data also showed that there were greater increases in excitability with the 35 cm(2) electrodes. Further, repeated sessions of tDCS with the 35 cm(2) electrodes ...Continue Reading

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Citations

Apr 18, 2016·Neuropsychologia·Dennis J L G Schutter, Miles Wischnewski
Jul 5, 2016·Frontiers in Human Neuroscience·Tjeerd W BoonstraColleen K Loo
May 12, 2016·Journal of Cognitive Neuroscience·Jacky AuJohn Jonides
Dec 15, 2016·Frontiers in Neuroscience·Suman DasOpher Donchin
Dec 8, 2017·Frontiers in Neuroscience·Hayley ThairAlastair D Smith
Oct 19, 2017·Neurodegenerative Disease Management·Celina S LiuNathan Herrmann
Aug 11, 2018·The Journal of ECT·Dennis Q Truong, Marom Bikson
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May 5, 2018·Frontiers in Psychology·Bastien TrémolièreIsabelle Blanchette
Jan 23, 2019·Frontiers in Neuroscience·Sheida RabipourFrançois Tremblay
May 21, 2019·Frontiers in Human Neuroscience·Steven E Davis, Glen A Smith
Jun 17, 2020·Journal of Neuroengineering and Rehabilitation·Victor Spiandor BerettaRodrigo Vitório
Nov 3, 2020·Cerebral Cortex·Francesca VitaleManuel de Vega
Jul 21, 2020·Neuropsychologia·Charlotte E E Wiltshire, Kate E Watkins
Feb 27, 2021·Experimental Brain Research·Tribikram ThapaSiobhan M Schabrun
Oct 27, 2017·Brain Stimulation·Molly E McLarenAdam J Woods
Apr 3, 2021·Cognitive, Affective & Behavioral Neuroscience·Ulrike SenftlebenStefan Scherbaum
Nov 12, 2018·Neurophysiologie clinique = Clinical neurophysiology·Charlotte Brevet-AebyJérome Brunelin
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Jul 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Xiaoyun LiWeiwei Peng

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