The effect of transdermal oestradiol on bleeding pattern, hormonal profiles and sex steroid receptor distribution in the endometrium of Norplant users

Human Reproduction
W BoonkasemsantiP Wannakrairot

Abstract

The most common side-effect and reason for discontinuation with Norplant use is bleeding disturbance. The aim of this study was to investigate whether the 6 week application of a patch which released 100 micrograms/day oestradiol would reduce the number of abnormal bleeding days or eliminate the problem. Another objective was to find out the correlation between the bleeding pattern and endometrial concentrations of oestrogen receptor (ER) and progesterone receptor (PR). Of 98 Norplant users, 34 patients had normal bleeding patterns and 64 patients had abnormal bleeding patterns. An oestradiol patch or a placebo patch were randomly used to treat 33 and 31 women with abnormal bleeding respectively. There was a clinical improvement in the oestradiol group compared with the placebo group, although this was not statistically significant. There were no correlations between PR and ER concentration and the serum oestradiol, progesterone, levonorgestrel and sex hormone-binding globulin concentrations. Significantly increased mean immunostaining scores of stromal PR were observed in those Norplant users whose endometrium had an atrophic histological appearance. The serum oestradiol concentration did not show a significant change after tr...Continue Reading

Citations

Dec 22, 2000·Contraception·P Chotnopparatpattara, S Taneepanichskul
Jul 15, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·Anne Gompel
Nov 15, 2011·Diabetes, Obesity & Metabolism·C C LeeL-J Liang
Sep 11, 2012·Contraception·Petra M CaseyAmy L Weaver
Jun 23, 2004·Contraception·María Rebeca MassaiCatherine d'Arcangues
Nov 8, 2011·American Journal of Obstetrics and Gynecology·Tessa MaddenJeffrey F Peipert
Sep 24, 2009·Reproductive Biology and Endocrinology : RB&E·Carlo AlviggiStephen G Hillier
Dec 19, 2016·American Journal of Obstetrics and Gynecology·Rachel E Zigler, Colleen McNicholas

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