PMID: 8946256Dec 1, 1996Paper

The effect of transplanting one or two suprachiasmatic nuclei on the period of the restored rhythm

Journal of Biological Rhythms
F C Davis, N Viswanathan

Abstract

A fundamental property of circadian rhythms is the free-running period expressed by organisms when isolated from environmental periodicity. The physiological determinants of the free-running period, including variation among and within individuals and among species, are not known. The circadian rhythms of mammals are regulated by a circadian pacemaker within the suprachiasmatic nucleus (SCN) of the hypothalamus. To examine possible determinants of the free-running period, one or two SCNs were transplanted into hamsters that had their own SCNs ablated. Wheel-running behavior was measured to estimate the free-running period of restored rhythmicity. Hosts received grafts containing either the left or right SCN from a single fetus or both SCNs from a single fetus. In some cases, both the left and right SCNs from a single fetus restored rhythmicity in different hosts, demonstrating that each of the right and left SCN alone is a competent circadian pacemaker. The average free-running period of the restored rhythms was significantly longer in hamsters that received both of the SCNs from a single fetus. The sizes of grafts were estimated using immunoreactivity for vasoactive intestinal polypeptide as a marker of SCN tissue. Grafts neve...Continue Reading

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Citations

Apr 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Natsuko InagakiKen-ichi Honma
Jun 28, 2012·Chronobiology International·Yuval WeiglIsrael E Ashkenazi
Feb 22, 2013·Chronobiology International·Yuval WeiglShimon Amir
Dec 20, 2011·Revista española de geriatría y gerontología·Elisabet Ortiz-TudelaPilar Mendiola
Nov 24, 1998·Medical Hypotheses·T Partonen
Sep 7, 2000·Seminars in Perinatology·T L Shanahan, C A Czeisler
Oct 29, 2000·Science·H O de la IglesiaW J Schwartz

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