The effect of triacylglycerol-fatty acid positional distribution on postprandial metabolism in subcutaneous adipose tissue

The British Journal of Nutrition
L K SummersK N Frayn

Abstract

We hypothesized that fatty acids at the sn-2 position of chylomicron triacylglycerol are preferentially released into the venous plasma (rather than being taken up and stored in the adipocytes) after hydrolysis by lipoprotein lipase (EC 3.1.1.34) in adipose tissue. Arteriovenous differences across adipose tissue were studied in eight healthy subjects on two occasions for 6 h after ingestion of different structured triacylglycerols rich in palmitic acid either at the sn-2 or the sn-1,3 positions. In particular the specific fatty acids making up lipoprotein fractions and plasma non-esterified fatty acids were analysed. After the different meals there were no differences between either postprandial arterialized or venous plasma metabolite concentrations. Chylomicron triacylglycerol extraction in adipose tissue was the same following the two types of fat. There was no difference between the specific fatty acid composition of the postprandial non-esterified fatty acid release from adipose tissue after ingestion of the two triacylglycerols, indicating that there was no preferential release of a saturated fatty acid at the sn-2 position.

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Citations

May 10, 2005·The Proceedings of the Nutrition Society·Keith N Frayn
Dec 15, 2011·American Journal of Physiology. Endocrinology and Metabolism·Keith N Frayn, Sandy M Humphreys
May 3, 2002·The Journal of Physiology·Fredrik KarpeKeith N Frayn
May 28, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Asim K Duttaroy
May 11, 2007·Nutrition & Metabolism·Youssef TahiriKatherine Cianflone
Apr 30, 2013·Progress in Lipid Research·M C MichalskiUNKNOWN Steering Committee of RMT LISTRAL
Nov 6, 2010·Nutrition & Metabolism·Salwa W Rizkalla
Jun 25, 2010·Diabetology & Metabolic Syndrome·Jose D BotezelliMaria A Mello
Sep 4, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Angela A RivelleseGabriele Riccardi
Jun 21, 2006·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Lucinda Km Summers
Dec 3, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J-L ArdilouzeB A Fielding
Mar 18, 2005·Nature·Simon Mawer
Jun 6, 2000·The American Journal of Clinical Nutrition·L K SummersK N Frayn
Jul 22, 2017·Nutrition Bulletin·C E MillsS E E Berry
Aug 10, 2006·The American Journal of Clinical Nutrition·Yolanda M PachecoFrancisco J G Muriana

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