PMID: 8939050Dec 1, 1996Paper

The effect of Trichinella spiralis infection on the mechanical properties of the mammalian diaphragm

Parasitology
C L HarwoodJ D Altringham

Abstract

Trichinella spiralis larvae infect and develop within skeletal muscle cells causing major changes to their mechanical properties. The aim of this investigation was to determine the effects of T. spiralis on the power output and fatigue resistance of the mammalian diaphragm under conditions simulating in vivo operation and to relate these to respiratory performance. Infection with T. spiralis leads to major reductions in mechanical stress, work, power output and fatigue resistance. These changes are associated with the number of larvae present in the muscle and the duration of infection. However, the initial decline in mechanical performance occurs during the onset of infection when there are few larvae observed within the muscle cells, indicating that T. spiralis may affect the properties of muscle before encapsulation. This may correspond to the host's inflammatory response and the effects of larval excretory/secretory products. The decline in mechanical performance will have a profound effect on respiration both at rest and during exertion. This must influence the behaviour of the host and increase its chance of capture by predators, which is likely to benefit the parasite by facilitating its transmission.

References

Sep 1, 1977·The Journal of Cell Biology·G F Gauthier, S Lowey
Feb 1, 1978·Experimental Parasitology·M A Casey, J P Harley
Feb 1, 1977·Experimental Parasitology·K N Farris, J P Harley
Feb 1, 1975·Experimental Parasitology·D DespommierL Turgeon
Jan 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·R C KoD L Lee
May 1, 1990·Experimental Parasitology·D P Jasmer
Oct 1, 1989·Canadian Journal of Physiology and Pharmacology·D A Syme, E D Stevens
Apr 1, 1985·Journal of Applied Physiology·J M MetzgerR H Fitts
Jan 1, 1968·Virchows Archiv. A: Pathology. Pathologische Anatomie·D Ribas-Mujal, J M Rivera-Pomar
Sep 1, 1972·Journal of the Neurological Sciences·N T James
Feb 1, 1966·The Journal of Cell Biology·G F Gauthier, H A Padykula
Dec 1, 1984·Parasitology·M E Rau, L Putter
Mar 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·J Ochoa, C Pallis
Jan 1, 1993·Annual Review of Physiology·R K Josephson

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Citations

Feb 2, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Yeun Ying WongWillem J van der Laarse

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