Jun 1, 1976

The effect of trimepranol on the binding of [3H] norepinephrine in myocardial subcellular fractions of the dog

Archives Internationales De Pharmacodynamie Et De Thérapie
J Nedvídková, V Felt

Abstract

The effect of Trimepranol on the binding of 3H norepinephrine to myocardial particles from dogs (to fractions 1,000 g and 78,000 g resp.) has been studied and compared with the effect of propranolol, isoprenaline, phentolamine and ephedrine. Displacement of 3H norepinephrine by propranolol and isoprenaline was found in both fractions. Trimepranol, in low concentrations, inhibited the binding of 3H norepinephrine; in higher concentrations the binding of 3H norepinephrine was stimulated. Phentolamine and ephedrine were without effect in both fractions. The problem of specificity of adrenergic binding sites is discussed.

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Mentioned in this Paper

Myocardium
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Antagonists
Ephedrine
Plasma Protein Binding Capacity
Propanolamines
Norepinephrine
Respiratory, Thoracic and Mediastinal Disorders
Norepinephrine Measurement
Subcellular Fractions

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