PMID: 7527257Aug 1, 1994Paper

The effect of tripotassium dicitrato bismuthate on the rat stomach

Alimentary Pharmacology & Therapeutics
H L WaldumA K Sandvik

Abstract

Bismuth has been used as symptomatic treatment of dyspepsia for many years. It promotes healing of peptic ulcers and reduces their recurrence. The beneficial effect of bismuth on duodenal ulcer disease is thought to be due to an effect on Helicobacter pylori, although it has a rather weak bactericidal effect on H. pylori in vitro. Eradication of H. pylori in duodenal ulcer patients by a combination of bismuth, tetracycline and metronidazole has been reported to increase the density of somatostatin-producing D cells in the antrum. A reduced D cell density in the antral mucosa of duodenal ulcer patients could explain their exaggerated gastrin release. To test the possibility that bismuth could affect the neuroendocrine cells independently of the presence of H. pylori or not, we gave rats a diluted tripotassium dicitrato bismuthate solution by gastric gavage for 14 days. Tripotassium dicitrato bismuthate treatment did not affect maximal pentagastrin-stimulated acid secretion or histamine release in isolated rat stomachs or the density of argyrophil cells in the oxyntic and antral mucosa. However, it significantly reduced the duodenal concentration of gastrin and calcitonin gene-related peptide, and the density of G cells in the an...Continue Reading

References

Jun 1, 1992·Gastroenterology·M TsujiiN Sato
Jan 1, 1992·Scandinavian Journal of Gastroenterology·R S ChittajalluK E McColl
Jun 1, 1991·Alimentary Pharmacology & Therapeutics·E J PrewettR E Pounder
Jan 1, 1991·Digestive Diseases and Sciences·S KawanoT Kamada
Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·H L WaldumB Schulze Søgnen
May 1, 1990·Journal of Virology·J M LöhrM B Oldstone
Oct 1, 1988·The Journal of Allergy and Clinical Immunology·A M Morel, M A Delaage
Mar 1, 1989·Scandinavian Journal of Gastroenterology·H L Waldum, A K Sandvik
Feb 1, 1989·Alimentary Pharmacology & Therapeutics·C J GaveyR E Pounder
Sep 1, 1989·Medical Toxicology and Adverse Drug Experience·A Slikkerveer, F A de Wolff
Dec 1, 1985·Antimicrobial Agents and Chemotherapy·C A McNultyR Wise
Jan 1, 1988·Annals of Internal Medicine·C P Dooley, H Cohen
Jun 18, 1987·The New England Journal of Medicine·B DrummM Karmali
May 7, 1983·British Medical Journal·J M Polak, S R Bloom
Dec 1, 1993·Gastroenterology·M MurakamiT Kita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.