The effect of troxerutin on anxiety- and depressive-like behaviours in the offspring of high-fat diet fed dams

Archives of Physiology and Biochemistry
Parvin BayandorShirin Babri

Abstract

This study aimed at investigating the metabolic and behavioural effects of troxerutin treatment in the offspring of high fat diet (HFD) fed dams. Female Wistar rats (n = 40) received normal diet (ND) or HFD for 8 weeks prior to breeding. After mating, pregnant animals were assigned to four subgroups: ND, ND + Tro (troxerutin 150 mg/kg/day), HFD, and HFD + Tro. On the 21st day, male offspring were weaned and fed ND until 12 weeks old. Behavioural tests were performed on postnatal day (PND) 80 and 90. Compared to the controls, the HFD offspring showed more anxiety- and depressive-like behaviours, higher blood glucose, cholesterol, and cortisol levels. On the other hand, chronic troxerutin administration during gestation restored metabolic and behavioural changes to normal. In summary, troxerutin improved anxiety- and depressive-like behaviours, as well as metabolic status in the offspring of the HFD fed dams. More studies are needed to determine the underlying mechanisms.

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Citations

May 8, 2020·Animal Science Journal = Nihon Chikusan Gakkaihō·Yasin BagheriMasoud Delashoub
Sep 1, 2018·Archives of Physiology and Biochemistry·Ghazal RahmaniHadi Ebrahimi
Apr 10, 2021·Journal of Pharmacopuncture·Zahra AhmadiMilad Ashrafizadeh
Jul 30, 2021·Neuroscience and Biobehavioral Reviews·Minerva Ortiz-ValladaresNorma Angélica Moy-López

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