The effect of tumor location on oncologic outcomes in patients with upper urinary tract urothelial carcinoma stratified by pathologic stage

Urologic Oncology
Yi-Sheng TaiYeong-Shiau Pu

Abstract

The aim of this study was to investigate the effect of tumor location on oncologic outcomes in patients with upper urinary tract urothelial carcinoma (UTUC) stratified according to pathologic stage. Between January 1996 and March 2009, 503 patients with UTUC were enrolled who had undergone radical nephroureterectomies and had no nodal or distal metastases. Preoperative chemotherapy or radiation therapy was not administered to any study patient. Clinicopathologic patient characteristics were obtained and used to analyze recurrence-free survival (RFS), cancer-specific survival, and overall survival with the Cox proportional hazards model. During the median follow-up of 52 months, patients with pathologic tumor (pT) stage 3 ureteral tumors had a shorter duration of RFS compared with those with pT3 renal pelvis tumors (5-y RFS: 50% and 71%, P = 0.047). There was no prognostic relevance to the tumor location in pTa/Tis/T1 and pT2 diseases. RFS and cancer-specific survival were significantly shorter in duration in pT3 ureteral disease compared with pT2 diseases (P<0.001 and P = 0.028). No differences were found in oncologic outcomes between pT3 renal pelvic and pT2 diseases. The presence of pT3 ureteral tumors actually increased the ...Continue Reading

References

Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Chung-Hsin ChenArthur P Grollman

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Citations

Jan 19, 2018·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Shreyas S JoshiSanjay G Patel
Jan 10, 2021·Virchows Archiv : an International Journal of Pathology·Tomoyasu SanoToyonori Tsuzuki
Dec 15, 2020·Investigative and Clinical Urology·Jae Wook ChungHyun Tae Kim

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