The effect of tumor location on prognosis in patients treated with radical nephroureterectomy at Memorial Sloan-Kettering Cancer Center.

European Urology
Ricardo L FavarettoGuido Dalbagni

Abstract

The prognostic impact of primary tumor location on outcomes for patients with upper-tract urothelial carcinoma (UTUC) is still contentious. To test the association between tumor location and disease recurrence and cancer-specific survival (CSS) in patients treated with radical nephroureterectomy (RNU) for UTUC. Prospectively collected data were retrospectively reviewed from 324 consecutive patients treated with RNU between 1995 and 2008 at a single tertiary referral center. Patients who had previous radical cystectomy, preoperative chemotherapy, previous contralateral UTUC, or metastatic disease at presentation were excluded. This left 253 patients for analysis. Tumor location was categorized as renal pelvis or ureter based on the location of the dominant tumor. Recurrences in the bladder only, in nonbladder sites, and in any site were analyzed. All patients were treated with RNU. Recurrence-free survival and CSS probabilities were estimated using Kaplan-Meier and Cox regression analyses. Median follow-up for survivors was 48 mo. The 5-yr recurrence-free probability (including bladder recurrence) and CSS estimates were 32% and 78%, respectively. On multivariable analysis, pathologic stage was the only predictor for disease recu...Continue Reading

References

Sep 25, 1997·Urology·E R Tawfiek, D H Bagley
Aug 24, 2005·European Urology·H G van der PoelS Horenblas
Jan 22, 2009·Cancer·Vitaly MargulisUNKNOWN Upper Tract Urothelial Carcinoma CollaborationThe Upper Tract Urothelial Carcinoma Collaboration
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Citations

May 4, 2012·World Journal of Urology·Marco CosentinoHumberto Villavicencio-Mavrich
Feb 26, 2011·International Urology and Nephrology·Bogomir MilojevicCane Tulic
Dec 12, 2012·International Urology and Nephrology·Shuichi MorizaneAtsushi Takenaka
Jan 17, 2012·Japanese Journal of Clinical Oncology·Katsura HoshinoMototsugu Oya
Sep 24, 2013·International Urology and Nephrology·Dragica Milenkovic-PetronicZoran Dzamic
Nov 28, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·V ElaloufE Xylinas
Nov 1, 2011·Actas urologicas españolas·M RouprêtUNKNOWN European Association of Urology Guideline Group for urothelial cell carcinoma of the upper urinary tract
May 1, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·C Le GouxM Zerbib
Feb 19, 2013·Urologic Oncology·Andrew K WilliamsJonathan I Izawa
Oct 2, 2012·The Journal of Urology·David A GreenShahrokh F Shariat
May 15, 2012·European Urology·Evanguelos XylinasUNKNOWN Upper Tract Urothelial Carcinoma Collaboration
Feb 22, 2012·European Urology·Michael RinkUNKNOWN Upper Tract Urothelial Carcinoma Collaboration (UTUCC)
Oct 7, 2011·European Urology·Thomas F ChromeckiShahrokh F Shariat
Mar 17, 2015·International Urology and Nephrology·Zoran DzamicSandra Sipetic Grujicic
Apr 22, 2016·World Journal of Urology·Aurélie MbeutchaShahrokh F Shariat
Mar 5, 2015·Cancer Treatment Reviews·Jeffrey J LeowJoaquim Bellmunt
Nov 5, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Pei LiuLi-Qun Zhou

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