The effect of two clinically relevant fusionless scoliosis implant strategies on the health of the intervertebral disc: analysis in an immature goat model

Spine
Kenneth J HuntBryt A Christensen

Abstract

Immature goat spines were instrumented at 5 levels with 2 different fusionless scoliosis implants. Instrumented and subadjacent spinal segments were analyzed to determine the effect on the disc and endplate. Analyze the regional biochemistry and histology of spinal motion segments in healthy goat spines treated with 2 clinically relevant, fusionless scoliosis implants. Fusionless scoliosis surgery is thought to be more physiologic than fusion as it preserves the growth, motion, and function of the spine. There are presently little data supporting this belief. Scoliosis was created in twelve 8-week-old female goats (n = 6 per group) using 1 of 2 fusionless scoliosis implant strategies: 2 SMA staples per level or a bone anchor/ligament tether. A third group served as controls (n = 6). Goats were analyzed after 6 months. Qualitative and quantitative analyses were performed on spinal motion segments using H&E, TUNEL, and caspase-3 staining. Neither implant strategy produced degenerative changes in the disc. However, discs at instrumented levels in both groups demonstrated decreased cell density (P < 0.01) and increased cellular apoptosis (P < 0.001) compared to controls. Subadjacent discs demonstrated preservation of viable cells a...Continue Reading

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Citations

Aug 21, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Eliane C SchmidStefan Parent
Jul 15, 2011·Medical & Biological Engineering & Computing·Mark DriscollStefan Parent
Jul 30, 2014·The Spine Journal : Official Journal of the North American Spine Society·Jiaming LiuXuhong Xue
Jan 28, 2015·Orthopaedics & Traumatology, Surgery & Research : OTSR·V Cunin
Jul 28, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Anne-Laure MénardIsabelle Villemure
Sep 28, 2013·Revista española de cirugía ortopédica y traumatología·D M Farrington, A Tatay-Díaz
Apr 16, 2013·The Spine Journal : Official Journal of the North American Spine Society·Alex K RothLodewijk W van Rhijn
Jul 3, 2013·Journal of Children's Orthopaedics·Joseph H CarreauPeter O Newton
Sep 12, 2015·Der Orthopäde·A SchulzeM Tingart
Apr 9, 2011·The Spine Journal : Official Journal of the North American Spine Society·Michiel M A JanssenRené M Castelein
Jul 8, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carl-Éric AubinJeremy Rawlinson
Jul 3, 2013·Journal of Pediatric Orthopedics·Gokhan DemirkiranMuharrem Yazici
Sep 1, 2013·Spine Deformity·Peter O NewtonChristine L Farnsworth

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis