The effect of two different domperidone doses on maternal milk production

Journal of Human Lactation : Official Journal of International Lactation Consultant Association
David C KnoppertOrlando P daSilva

Abstract

The benefits of breast milk to the newborn infant are well established. The Canadian Paediatric Society recommends exclusive breastfeeding for the first 6 months of life for healthy, term infants. Mothers of premature newborns, however, may have difficulty providing an adequate supply of breast milk. Domperidone is officially used as a prokinetic agent. However, it is used widely around the world as a galactogogue. Despite its widespread use as a galactogogue, only a small number of investigators have studied domperidone for this indication. The purpose of this study was to determine an optimal dosage of domperidone as a galactogogue. Eligible subjects were randomized to receive domperidone 10 mg 3 times daily or domperidone 20 mg 3 times daily for 4 weeks. At week 5, the frequency was decreased to twice daily in both groups, and finally once daily for week 6. Over the entire first 4-week period, there was a significant increase in daily milk volumes within each group (P < .01). The between-group difference over this period, although not statistically significant, was clinically significant. Additionally, there was no significant within- or between-group difference during weeks 5 and 6. A dose of domperidone of 20 mg, 3 times d...Continue Reading

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References

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Citations

Sep 1, 2012·BMC Pregnancy and Childbirth·Elizabeth V AsztalosShinya Ito
Jun 10, 2016·CMAJ Open·Kate SmolinaBarbara Mintzes
Jun 7, 2014·Journal of Chromatographic Science·Laura Curtin WhelanPaul Sweetman
Dec 3, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Luc M Hondeghem, Noël H Logghe
Feb 26, 2016·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Barbara HaaseCarol L Wagner
Dec 6, 2014·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Catherine PaulDavid Balayssac
Jan 2, 2013·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Philip O Anderson
Oct 31, 2014·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Luke E GrzeskowiakAndrea L Fielder
Mar 25, 2014·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Jack Ferrier
Feb 23, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·L E GrzeskowiakR M Grivell
Jan 21, 2017·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Elizabeth V AsztalosUNKNOWN EMPOWER Study Collaborative Group
Jun 15, 2018·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Wendy Brodribb
May 19, 2020·The Cochrane Database of Systematic Reviews·Siew Cheng FoongJoo Howe Ong
Nov 29, 2017·Alternative & Complementary Therapies : a New Bimonthly Publication for Health Care Practitioners·Jill R DemirciDebra L Bogen
Nov 10, 2018·Maternal Health, Neonatology and Perinatology·Elizabeth V AsztalosUNKNOWN EMPOWER Study Collaborative Group
Dec 14, 2018·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Elizabeth V AsztalosUNKNOWN <italic>EMPOWER</italic> Study Collaborative Group
Jun 7, 2019·International Breastfeeding Journal·Elizabeth V AsztalosUNKNOWN EMPOWER Study Collaborative Group
Nov 18, 2020·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Meera KhoranaWiboon Kanjanapattanakul

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Methods Mentioned

BETA
sandwich immunoassay

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PASW Statistics

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