PMID: 11917198Mar 28, 2002Paper

The effect of type II diabetes mellitus on platelet aggregation in patients who underwent percutaneous transluminal coronary angioplasty

Coronary Artery Disease
Abdi SağcanMustafa Akin

Abstract

In noninsulin-dependent type II diabetic (tIIDM) patients it was reported that ADP-induced platelet aggregation response was increased with decreased level of platelet guanylate cyclase. This study was therefore designed to examine the effects of tIIDM on collagen-induced, in-vitro platelet aggregation in percutaneous transluminal coronary angioplasty (PTCA) patients. Twenty patients with tIIDM and 30 nondiabetic patients who had successful PTCA were included in the study. Platelet-rich plasma samples from the patients before and after PTCA were treated with in-vitro collagen and platelet aggregation waves were calculated via the turbidometric method of Born. The maximum amplitude (%) and the ratio of changes after PTCA in the study participants were measured by these waves and data were compared by student's t tests and nonparametric methods. The maximum amplitude of collagen-induced platelet aggregation before and after the procedure was also compared using variant analysis. The change in collagen-induced maximum amplitude of platelet aggregation in both wave 1 and wave 2 was significantly more (P < 0.001- P < 0.001) in the tIIDM group. The ratio of restenosis seen in the control coronary angiography made 6 months after inter...Continue Reading

References

Jan 1, 1979·Acta Haematologica·P K KhoslaA K Saraya
Jun 1, 1975·Annals of Internal Medicine·J SagelM Laimins
Jan 1, 1991·Diabetes Research and Clinical Practice·O Ziegler, P Drouin
Oct 16, 1986·The New England Journal of Medicine·D J FitzgeraldG A FitzGerald
Aug 1, 1982·The Tohoku Journal of Experimental Medicine·H OnoderaY Goto
Oct 1, 1995·Journal of Diabetes and Its Complications·M NishimuraK Yamada
May 1, 1996·Journal of the American College of Cardiology·H J Oskarsson, T G Hofmeyer
Mar 25, 2000·Journal of the American College of Cardiology·D L BhattE J Topol
Nov 14, 2000·The American Journal of Cardiology·J L VelianouD R Holmes

❮ Previous
Next ❯

Citations

Jan 29, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Anna M Dyszkiewicz-KorpantyRavindra Sarode
Jul 10, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Andreas SchäferKeith M Channon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.