PMID: 3759651Jul 1, 1986Paper

The effect of ubenimex on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach tumor in rats

The Journal of Antibiotics
K EbiharaH Umezawa

Abstract

The effect of ubenimex on the progression of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced stomach tumor in rats was studied. Tumor induction was performed by giving MNNG via drinking water for 34 weeks. Ubenimex was ip administered twice a week at 0.5 mg/kg for 84 weeks in one group and 49 weeks in another starting from the first and 36th weeks after initiation of MNNG administration, respectively. The stomachs were endoscopically examined 2 times. At the 64th week after initiation of MNNG administration tumorous lesions were observed with about 70% of the rats in both ubenimex administration groups. In the ubenimex non-administration group nearly 90% of the rats had the lesions. After completion of ubenimex administration almost all the rats had the lesions in the three groups but the sizes were much smaller with the two ubenimex administration groups. Almost all of these lesions were histopathologically identified as tumorous. The tumor volume per rat in the two ubenimex administration groups from the 1 and 36th weeks was 21.0 and 19.2% of the volume in the control group, respectively. Tumor number per rat was similar among the three groups. The natural killer activity of rats was also examined after completion of the ...Continue Reading

Citations

Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·F AbeJ E Talmadge
Jul 1, 1993·Archiv der Pharmazie·R HerranzS Vinuesa
Oct 11, 2005·Medicinal Research Reviews·Brigitte Bauvois, Daniel Dauzonne
Jul 17, 2003·Journal of the National Cancer Institute·Xiaoxin ChenChung S Yang
Apr 17, 2003·Journal of the National Cancer Institute·Yukito IchinoseUNKNOWN NK421 Lung Cancer Surgery Group

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