The effect of ubiquinone and combined antioxidant therapy on oxidative stress markers in non-proliferative diabetic retinopathy: A phase IIa, randomized, double-blind, and placebo-controlled study

Redox Report : Communications in Free Radical Research
Adolfo Daniel Rodríguez-CarrizalezAlejandra Guillermina Miranda-Díaz

Abstract

Objective To evaluate the effect of ubiquinone (Coenzyme Q10) and combined antioxidant therapy (CAT) on oxidative stress markers in non-proliferative diabetic retinopathy (NPDR) under clinical management. Study design In a randomized, double-blind, phase IIa, placebo-controlled, clinical trial, three study groups were formed and administered medications as follows: Group 1, Coenzyme Q10; Group 2, CAT; and Group 3, placebo. Methods Serum levels of the products of lipid peroxidation (LPO) and nitrites/nitrates, as markers of oxidative/nitrosative stress, were measured. As antioxidants, the total antioxidant capacity (TAC), catalase activity, and glutathione peroxidase (GPx) activity were measured. Results Baseline serum levels of LPO and nitrites/nitrates were significantly elevated in the three groups vs. healthy group (P < 0.0001), while final levels in the Coenzyme Q10 and CAT groups were decreased vs. normal levels (P < 0.0001). The baseline TAC was consumed in the three groups (P < 0.0001), while final results in the Coenzyme Q10 and CAT groups improved (P < 0.0001). Baseline catalase activity was increased in all groups vs. normal values (P < 0.001), while final levels in the Coenzyme Q10 (P < 0.001) and CAT groups (P < 0.0...Continue Reading

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Citations

Dec 30, 2017·Journal of Drug Targeting·Parul ThakurAwanish Kumar
Apr 8, 2020·Oxidative Medicine and Cellular Longevity·Ricardo Raúl Robles-RiveraAdolfo Daniel Rodríguez-Carrizalez
Jan 1, 2020·Journal of Diabetes and Metabolic Disorders·Ozra Tabatabaei-MalazyBagher Larijani
Jun 26, 2020·European Journal of Clinical Pharmacology·Abolfazl AkbariSadegh Dehghani
Feb 14, 2018·Expert Opinion on Therapeutic Targets·Renu A Kowluru, Manish Mishra
Sep 13, 2019·Journal of Diabetes Research·Olvera-Montaño CeciliaRodríguez-Carrizalez Adolfo Daniel
May 1, 2021·International Journal of Molecular Sciences·Enrique Antonio Alfonso-MuñozCarmen Desco

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