PMID: 9170166Feb 1, 1997Paper

The effect of ultraviolet B induced adult T cell leukemia-derived factor/thioredoxin (ADF/TRX) on survival and growth of human melanocytes

Pigment Cell Research
Y Funasaka, M Ichihashi

Abstract

Ultraviolet B (UVB) radiation is known to induce reactive oxygen species (ROS) in the skin. The skin, however, counteracts ROS by both constitutional and newly produced antioxidants. One such antioxidant, adult T cell leukemia-derived factor (ADF), a human homologue of thioredoxin (TRX), was shown to be efficiently produced in and released from cultured normal human keratinocytes after UVB irradiation by Northern and Western blot analyses and enzyme-linked immunoabsorbent assay (ELISA). Recombinant ADF (rADF) did not rescue UVB-induced melanocyte death, either when added pre- or post-UV irradiation. However, further addition of neutralizing antibody caused cell death of both keratinocytes and melanocytes. rADF was shown to induce higher expression in melanocortin-1 receptor (MC1-R) mRNA accompanied by increased binding activity using 125I labeled [Nle4, D-Phe7]-alpha-MSH in melanocytes, leading to the enhanced increment of DNA synthesis. Taken together, it was shown that released ADF from UVB-irradiated keratinocytes acts as a survival factor for both keratinocytes and melanocytes but does not rescue UV-induced melanocyte death. Further, it may work as one of the stimulatory factors for UVB-induced melanogenesis by upregulating...Continue Reading

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Citations

Mar 18, 2004·Antioxidants & Redox Signaling·Dipak K Das
Apr 7, 2010·Antioxidants & Redox Signaling·Christoph UferHartmut Kuhn
Mar 13, 2012·Photochemistry and Photobiology·Nityanand MaddodiVijayasaradhi Setaluri
Jul 7, 2009·International Journal of Radiation Biology·Benjamin HaleyGayle E Woloschak
May 15, 2008·Photodermatology, Photoimmunology & Photomedicine·Tomoe KuharaYoshinari Matsumoto
Jul 12, 2005·Peptides·Francois Rouzaud, Vincent J Hearing
Mar 15, 2006·Current Opinion in Anaesthesiology·Dipak K Das, Nilanjana Maulik
Aug 11, 2020·Equine Veterinary Journal·Claire O'BrienChavaunne Thorpe
Sep 26, 2020·Access Microbiology·Masoud YoussefiMasoud Keikha
Aug 27, 1999·Biochemical and Biophysical Research Communications·O MoroO Ifuku

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