The effect of UV-B irradiation on secondary epidermal infection of mice with herpes simplex virus type 1

The Journal of General Virology
A A el-Ghorr, M Norval

Abstract

Previous studies have indicated that suberythemal ultraviolet B (UV-B) irradiation of C3H mice before primary infection with herpes simplex virus (HSV) type 1 does not result in increased morbidity or mortality, but a suppressed delayed type hypersensitivity (DH) to the virus can be demonstrated. Any effect of UV radiation on pathogenesis during secondary epidermal HSV infection has not been previously examined. Mice were immunized by subcutaneous injection of inactivated HSV and, 5 days later, one group was UV-B-irradiated. The next day all mice were challenged epidermally with HSV. Most of the mice (92%) in the irradiated group developed severe lesions, whilst 59% of the non-irradiated group had mild lesions and 30% no lesions. Infectious virus was not isolated from the adrenal glands after challenge in either group. In addition, the DH to the virus was not affected by the UV exposure. The numbers of lymphocytes and dendritic cells in the lymph nodes draining the site of epidermal infection were increased in the UV group compared with the non-irradiated group. Following challenge, the percentage of CD4+ and CD8+ lymphocytes in lymph nodes was unaltered but the MHC class II expression on dendritic cells in these lymph nodes wa...Continue Reading

Citations

Jan 27, 1999·Mutation Research·M Norval, A A El-Ghorr
Dec 19, 2000·FEMS Immunology and Medical Microbiology·A A El-GhorrM Norval
May 22, 1998·Journal of Photochemistry and Photobiology. B, Biology·J GarssenH Van Loveren
Sep 17, 2002·Methods : a Companion to Methods in Enzymology·Annemarie SleijffersHenk Van Loveren
Jun 30, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mary Norval, Gregory M Woods
Mar 21, 2002·Immunology and Cell Biology·G J ClydesdaleH K Muller
May 15, 1998·Photodermatology, Photoimmunology & Photomedicine·A A El-GhorrM Norval
Aug 1, 1996·Photochemistry and Photobiology·M Norval, A A el-Ghorr
May 1, 1997·Photochemistry and Photobiology·A A el-Ghorr, M Norval
Dec 7, 2000·Photochemistry and Photobiology·J GarssenH van Loveren
Oct 5, 2006·Photochemistry and Photobiology·Mary Norval
Jun 13, 2015·The Journal of Investigative Dermatology. Symposium Proceedings·Thomas Schwarz
Jul 25, 2009·The Journal of Investigative Dermatology·Thomas Schwarz
Oct 30, 2008·Journal of Immunotoxicology·Annemarie SleijffersHenk Loveren

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