May 1, 1989

The effect of UV-radiation, heating and acidic pH on the antigenic activity of influenza virus nucleoproteins

Voprosy virusologii
E N ProkudinaS S Iamnikova

Abstract

The capacity of influenza virus nucleoprotein (NP) to bind monoclonal antibodies upon virus treatment with factors affecting the conformation condition of the protein: ultraviolet irradiation, heating to 100 degrees C, acid pH, was studied. Upon the action of these factors NP epitopes demonstrated different time course of inactivation which suggests that they differ in their structural organization and, possibly, in their position in NP. From the possibility of formation in UV-irradiated virus of RNA-protein linkings, the UV-resistant epitope of NP is considered to be most distant from RNA as compared with other epitopes.

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Mentioned in this Paper

Monoclonal Antibodies
Monoclonal antibodies, antineoplastic
Nucleoproteins
Antigenic Specificity
Influenza
Hot Temperature
MUROMONAB-CD3, Parenteral,5 MG Administered
Morphogenesis
Orthomyxovirus Type A, Porcine
Acids

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