PMID: 2495343Apr 1, 1989Paper

The effect of valproic acid on 65Zn distribution in the pregnant rat

The Journal of Nutrition
C L KeenL S Hurley

Abstract

The effect of valproic acid on the distribution of gavaged 65Zn in maternal and embryonic tissue of Sprague-Dawley rats was examined 24 h after gavaging of the drug on d 13 of pregnancy. Valproic acid treatment resulted in a significantly higher retention of 65Zn in maternal liver and lower amounts in uterus, placenta and embryos than in controls. Compared to controls, gel chromatography of maternal liver from valproic acid-treated dams showed higher 65Zn counts associated with a protein peak of molecular weight of 6,500, the approximate molecular weight of the Zn-binding protein metallothionein. These results support the idea that the teratogenicity of valproic acid is in part due to an induction of embryonic Zn deficiency secondary to a drug-induced sequestering of Zn into maternal liver that results in a decrease in maternal plasma Zn and subsequent reduction in embryonic Zn uptake.

Citations

Sep 4, 2004·Environmental Health Perspectives·Kim KultimaMichael Stigson
Oct 1, 1992·Teratology·A MilunskyW Willett
Mar 15, 1993·Annals of the New York Academy of Sciences·C L KeenM E Gershwin
Jan 1, 1995·Journal of Basic and Clinical Physiology and Pharmacology·D T SözüerS Onen
Feb 24, 2006·Pediatric Research·Joanne S C ChuaPeter Coyle
Feb 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yo OmataPatricia I Oteiza
Apr 22, 2019·Pharmacological Reports : PR·K P Singh, Niharika Verma
Mar 11, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Claire M SchreinerWilliam J Scott
Mar 1, 1991·The Proceedings of the Nutrition Society·R P Thompson
Nov 5, 2020·Avian Pathology : Journal of the W.V.P.A·Tommy Van LimbergenRichard Ducatelle
Jan 1, 1994·Reproductive Toxicology·M W TaubeneckC L Keen
Jan 1, 1991·Toxicology·M Kaji, H Mikawa

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