The effect of various fenoldopam doses on renal perfusion in patients undergoing cardiac surgery

The Annals of Thoracic Surgery
Massimo Meco, Silvia Cirri

Abstract

The hypothesis that fenoldopam mesylate, by increasing renal flow, could reduce renal damage in patients undergoing cardiac surgery with cardiopulmonary bypass has gained great interest. The aim of the current study was to quantify the relationship of the increase of the renal blood flow as a function of the fenoldopam dose in these patients and to evaluate renal flow distribution within the renal parenchyma using Doppler. Twenty-five patients admitted to cardiac surgery have been enrolled. We used the Doppler technique to measure renal blood flow at the level of the renal, segmental, interlobar, and interlobular arteries. We calculated both the resistive and pulsatility indexes in all the renal segments. Moreover, we calculated echographically all the variables of preload, afterload, and cardiac index. Measurements were performed at baseline and after the infusion of fenoldopam mesylate at the doses of 0.05, 0.1, 0.2, and 0.3 microg x kg(-1) x min(-1). Fenoldopam infusion at doses more than 0.1 microg x kg(-1) x min(-1) significantly increases blood flow in all renal compartments, thus improving the resistive and pulsatility indexes starting at a dose of 0.1 microg x kg(-1) x min(-1). The highest renal flow increase is observe...Continue Reading

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Citations

Dec 16, 2010·Current Opinion in Anaesthesiology·Matthew D ColemanRobert N Sladen
Nov 25, 2011·Journal of Veterinary Internal Medicine·V ChetboulH P Lefebvre
Jul 1, 2011·Critical Care : the Official Journal of the Critical Care Forum·Zaccaria RicciSergio Picardo
Aug 13, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Susan Garwood
Aug 25, 2010·The Annals of Thoracic Surgery·Guillermo Lema
Jan 28, 2010·The Annals of Thoracic Surgery·Marco Ranucci
Dec 1, 2014·Journal of Anesthesia·Gianni BiancofioreFranco Filipponi
Mar 27, 2012·Current Opinion in Pharmacology·Anthony M H Ho, Simon K C Chan
Oct 8, 2016·Annals of Cardiac Anaesthesia·Christian Ortega-LoubonEnrique Fulquet-Carreras
May 17, 2018·Journal of Nephrology·Valentina RovellaAnnalisa Noce
May 19, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gianluigi ArdissinoUNKNOWN ItalKid-HUS Network

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