PMID: 592063Dec 1, 1977

The effect of various resuscitative regimens on hemorrhagic shock in puppies

Journal of Pediatric Surgery
W E StrodelA G Coran

Abstract

Since shock secondary to hemorrhage is not infrequently encountered in the pediatric patient, a puppy model was devised to help measure and monitor cardiovascular and metabolic changes that occur before and after resuscitation from hypovolemic shock (mean arterial pressure of 50 mm Hg for 1 hr). Three resuscitation protocols were compared: whole blood (replacement:shed) 1:1, 5% albumin in Ringer's lactate 1:1; and Ringer's lactate 3:1. All dogs survived the experiment and responded similarly during the shock period. Thermal dilution cardiac output rose in all groups after resuscitation; however, in the Ringer's lactate and 5% albumin groups, cardiac output was statistically greater than that observed in the blood group. In all groups, pH and blood pressure approached but did not return completely to baseline levels after resuscitation. In addition, early resuscitation demonstrated a further decrease pH ("hidden acidosis") before it began to return toward normal as resuscitation progressed. This study suggests that the infusion of large volumes of Ringer's lactate or 5% albumin in Ringer's lactate are equally efficacious in the treatment of hemorrhage. However, 5% albumin seems to be preferable because it allows infusion of a sm...Continue Reading

References

Jan 1, 1975·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M SilberschmidC Lund
Apr 1, 1976·Surgery, Gynecology & Obstetrics·H LaksR N Pilon
Apr 1, 1968·Journal of Pediatric Surgery·M I Rowe, R A Arcilla
Jun 1, 1971·Journal of Pediatric Surgery·M I Rowe, A Arango
Sep 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·S NagyR A Huggins
Sep 1, 1969·Archives of Surgery·B D LoweryL C Carey

Citations

Dec 31, 2004·The Journal of Trauma·Julio A Clavijo-AlvarezJ C Puyana
Aug 1, 1980·Journal of Pediatric Surgery·J W BennerA G Coran
Apr 12, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·P MokaramiPer Olofsson
Sep 28, 2007·Journal of the Royal Army Medical Corps·M A Khan, J P Garner

Related Concepts

Albumins
Blood Gas Analysis
Blood Transfusion, Autologous
Canis familiaris
Hemodynamics
Lactates
Monitoring, Physiologic
Resuscitation Procedure
Hypovolemic Shock
Shock, Hemorrhagic

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