Jan 1, 1981

The effect of vasectomy on Sertoli cell function in rats

Investigative Urology
J D Harris, L I Lipshultz

Abstract

In order to evaluate Sertoli cell function after vasectomy, we studied a group of 24 rats. Twelve animals underwent bilateral vasectomy and 12 control animals underwent a sham operation. At 3 and 8 weeks postvasectomy, six experimental and six control animals were sacrificed. Forty-eight hours before sacrifice, the efferent ducts of the testes of each animal were ligated to produce intratesticular androgen-binding protein (ABP) accumulation. Quantification of ABP was determined using a steady-state polyacrylamide gel electrophoresis system and a 2 nM 3H-dihydrotestosterone label. The ABP of the vasectomized and control animals was expressed as both picomoles per milligram of protein and picomoles per organ and was found to be 0.28 +/- 0.06 and 0.42 +/- 0.09 for the control and vasectomized animals at 3 weeks and 0.46 +/- 0.07 and 0.52 +/- 0.08 for similar groups at 8 weeks. Comparison of these values revealed no statistical significance. Vasectomy, therefore, had no demonstrable effect on Sertoli cell function in the rat and our findings support the concept that ligation of the vas does not result in long-term biochemical testicular damage in the experimental animal.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Dihydrotestosterone Assay
Salicylhydroxamic acid
Structure of Sertoli Cell
Inferior Colliculus
Testis
Testicular Dysfunction
Testicular Diseases
Polyacrylamide Gel Electrophoresis
Androgen Binding Protein
Dihydrotestosterone

About this Paper

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Head And Neck Squamous Cell Carcinoma

Squamous cell carcinomas account for >90% of all tumors in the head and neck region. Head and neck squamous cell carcinoma incidence has increased dramatically recently with little improvement in patient outcomes. Here is the latest research on this aggressive malignancy.

Signaling in Adult Neurogenesis

Neural stem cells play a critical role in the production of neuronal cells in neurogenesis is of great importance. Of interest is the role signalling mechanisms in adult neurogenesis. Discover the latest research on signalling in adult neurogenesis.

Psychiatric Chronotherapy

Psychiatric Chronotherapy considers the circadian rhythm as a major factor for optimizing therapeutic efficacy of psychiatric interventions. Discover the latest research on Psychiatric Chronotherapy here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.