The effect of vegetarian diet on skin autofluorescence measurements in haemodialysis patients

The British Journal of Nutrition
Arkom Nongnuch, Andrew Davenport

Abstract

CVD remains the major cause of death for dialysis patients. Dialysis patients have both traditional and nontraditional risk factors, including the retention of advanced glycation end products (AGE). Tissue AGE can be measured by skin autofluorescence (SAF) and are a reliable measurement of chronic exposure. Dietary intake of AGE may be lower in vegetarian patients than in non-vegetarian patients, so we determined whether vegetarian patients had lower SAF than non-vegetarian patients. We measured SAF in 332 adult haemodialysis patients using a UV technique in a standardised manner. Information about patients' demographic data, laboratory results and current medicinal prescriptions was collected retrospectively from the hospital's computerised database. The mean patient age was 65·2 (SD 15·1) years, 64 % were men, 42 % were diabetic, and 66 % were Caucasian. The mean SAF was 3·26 (SD 0·95) arbitrary units (AU), and SAF was lower in vegetarians as compared to non-vegetarians (2·71 (SD 0·6) v. 3·31 (SD 0·97) AU, P= 0·002). SAF was negatively correlated on both univariate (r -0·17, P= 0·002) and multiple linear regression (β coefficient -0·39, 95 % CI -0·7, -0·07, P= 0·019). SAF, a marker of tissue AGE deposition, was reduced in veg...Continue Reading

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Citations

Apr 6, 2016·Hemodialysis International·Sakina KandouzAndrew Davenport
Jan 16, 2018·Nature Reviews. Nephrology·Peter StenvinkelRichard J Johnson
Oct 8, 2019·Current Opinion in Nephrology and Hypertension·Daniela Viramontes Hörner, Maarten W Taal
Jan 5, 2019·European Journal of Clinical Nutrition·Debora M SilvaMaria do Rosário G Peixoto
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jonas WizentyTilo Wuensch

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