The effect of VEGF on blood vessels and blood cells during Xenopus development

Biochemical and Biophysical Research Communications
Nobutaka KoibuchiRyuichi Morishita

Abstract

Vascular endothelial growth factor (VEGF) is known to play an essential role in vascular development. We have overexpressed VEGF122 or VEGF170, which are equivalent to mouse VEGF120 and VEGF164, in developing Xenopus embryos. Overexpression of VEGF170 but not VEGF122 demonstrated an absence of expression of hematopoietic markers alpha-globin and GATA-1 but only in the posterior portion of the blood island. Interestingly, strong signals of endothelial markers, msr, fli-1, and tie-2, were detectable in those regions, instead of hematopoietic markers. These results suggested both that injection of VEGF170 resulted in disturbance of vasculogenesis in the posterior portion of the blood island, with excessive production of endothelial cells at the expense of blood cells, and that the anterior and posterior portions of the VBI may have distinct characteristics.

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Citations

Jun 5, 2007·Biochemical and Biophysical Research Communications·Kaori NagaoRyuichi Morishita
Jun 18, 2010·Blood·Benjamin DrogatJody J Haigh
Mar 28, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Hiroki HayashiYasufumi Kaneda
Apr 3, 2014·Anatomy & Cell Biology·Jong-Chan LimMitsugu Maéno
Sep 20, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Joanne R DohertyPaul E Mead
Feb 28, 2008·The Journal of Biological Chemistry·Kaori NagaoRyuichi Morishita
Jun 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Arif KirmizitasRoger Patient
Oct 10, 2008·Development·Olga KazanskayaChristof Niehrs

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