PMID: 2509039Jun 1, 1989Paper

The effect of vitamin A and Astragalus on the splenic T lymphocyte-CFU of burned mice

Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns
S F Pang

Abstract

In present study the effects of vitamin A and Astargalus on the splenic TL-CFU of mice were studied by means of T-lymphocytes colony formation in semi-solid culture in vitro and incorporation of 3H-TdR. Marked reduction of the responsive reaction of TL-CFU and T-lymphocyte transformation were found. The TL-CFU of the experimentally burned mice untreated with vitamin A (i.e. group 1) were significantly inhibited (p less than 0.005) in comparison with the unburned control group (i.e. group 4). And the TL-CFU of the experimentally burned mice treated with vitamin A (i.e. group 3) increased significantly (p less than 0.005) in comparison with group 1. Incorporation of 3H-TbR showed that vitamin A might accelerate the proliferation of the TL-CFU of the burned mice. It means that vitamin A might be regarded as an effective agent for the reversal of the inhibition of cell-mediated immunity in post-burned state, whether Ahstragalus plays a role in regulating immune inhibition needs further investigation.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.