Abstract
Vitamin A supplementation has consistently reduced infant mortality and the severity of pathogen-induced diarrhea. The mechanism by which vitamin A modulates the mucosal immune response to produce these effects remains poorly defined. To address this issue, stools collected during the summer months from 127 Mexican children 5-15 mo old enrolled in a larger, randomized, double-blind, placebo-controlled, vitamin A supplementation trial were screened for interleukin (IL)-4, IL-6, interferon-gamma (IFN-gamma), and gastrointestinal pathogens. Fecal cytokine values were categorized into 3 levels (undetectable, <median, > or =median). Multinomial regression models were used to determine the probability that vitamin A-supplemented children had higher categorical values of a cytokine than children in the placebo group. Differences in categorical values were also analyzed after stratification by gastrointestinal pathogen infections and diarrheal symptoms. Overall, fecal cytokine categorical levels did not differ between children randomized to the 2 arms. Vitamin A-supplemented children infected with enteropathogenic E. coli (EPEC) had reduced IL-4 and IFN-gamma levels [odds ratio (OR) = 0.3, 95% CI 0.13-0.67 and OR = 0.34, 95% CI 0.14-0....Continue Reading
References
Sep 30, 1992·Statistics in Medicine·L Frison, S J Pocock
May 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M PasatiempoA C Ross
Oct 1, 1990·Veterinary Immunology and Immunopathology·S R SijtsmaA J van der Zijpp
May 1, 1968·The American Journal of Tropical Medicine and Hygiene·L K Martin, P C Beaver
Feb 1, 1995·The Journal of Infectious Diseases·R RaqibA A Lindberg
Jun 1, 1995·European Journal of Immunology·M T CantornaC E Hayes
Jun 1, 1995·The American Journal of Clinical Nutrition·U RamakrishnanE A Frongillo
Jun 1, 1995·Infection and Immunity·J M KlapprothS P James
Aug 1, 1993·Journal of Leukocyte Biology·V GrossM Lotz
Feb 1, 1996·The Journal of Nutrition·M J DibleyL H Moulton
May 1, 1999·The Journal of Nutrition·T NikawaK Kishi
Jul 27, 1999·Science·L M HigginsT T MacDonald
Mar 18, 2000·Infection and Immunity·J M KlapprothM S Donnenberg
May 10, 2000·The Journal of Nutrition·D CuiC B Stephensen
Mar 29, 2002·The Journal of Infectious Diseases·David E GreenbergHerbert L DuPont
May 9, 2002·Emerging Infectious Diseases·Luiz R TrabulsiTânia A Tardelli Gomes
Sep 5, 2002·Epidemiology and Infection·T Estrada-GarciaC Lopez-Saucedo
Nov 1, 2002·Journal of Clinical Microbiology·Zhi-Dong JiangHerbert L DuPont
Dec 7, 2002·The Journal of Nutrition·Kathleen A HoagColleen E Hayes
Apr 8, 2003·Scandinavian Journal of Gastroenterology·A KonradF Seibold
Apr 16, 2003·Parasite Immunology·Stefan M GeigerRodrigo Corrêa-Oliveira
Jul 29, 2003·International Immunology·Makoto IwataHiroyuki Kagechika
Aug 22, 2003·British Journal of Haematology·Mohamad MohtyDaniel Olive
Dec 25, 2004·Infection and Immunity·Karina RamirezFernando Navarro-Garcia
Citations
Jun 15, 2007·Nutrition Reviews·Kurt Z LongWafaie Fawzi
Oct 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Milena M VieiraAldo A M Lima
Apr 1, 2009·Infection and Immunity·Harry DawsonJoseph F Urban
Oct 5, 2010·Scandinavian Journal of Immunology·L Hein-KristensenC S Benn
Sep 17, 2013·Journal of Clinical Immunology·Rebecca J M HurstKathryn J Else
Aug 16, 2019·Parasites & Vectors·Gwendoline DeslyperJames C Carolan
Feb 15, 2007·The British Journal of Nutrition·Kurt Z LongJose Ignacio Santos
Sep 30, 2014·BMC Infectious Diseases·Rebecca J M HurstKathryn J Else
Mar 11, 2017·The Cochrane Database of Systematic Reviews·Aamer ImdadZulfiqar A Bhutta
Sep 22, 2006·The Journal of Nutrition·Kurt Z LongNanda N Nanthakumar
Apr 24, 2012·Journal of Parasitology Research·Liam ReillyFrancisca Mutapi
May 14, 2014·Ciência & saúde coletiva·Weslla Karla Albuquerque Silva de PaulaMalaquias Batista Filho
Nov 15, 2013·Virology Journal·Kaitlin J SoyeBrian J Ward
Dec 17, 2014·PloS One·Xia LiuJie Chen
Oct 3, 2018·Frontiers in Cellular and Infection Microbiology·Zhendong LiGuoqiang Zhu
Apr 16, 2019·Pathogens and Global Health·María Morales-Suarez-VarelaAgustin Llopis-Gonzalez
May 22, 2007·The Journal of Nutrition·Leslie G PayneMarilyn E Scott
Mar 27, 2012·Parasite Immunology·R J M Hurst, K J Else
Mar 18, 2011·The Journal of Nutrition·Kurt Z LongNanda Nathakumar
Dec 30, 2009·Infection and Immunity·Kurt Z LongTeresa Estrada-Garcia
Apr 29, 2011·The Journal of Nutrition·Mari S MangerNita Bhandari
Apr 18, 2014·The American Journal of Clinical Nutrition·Brechje de GierKatja Polman
Oct 3, 2007·Pediatrics·Kurt Z LongJose Ignacio Santos