PMID: 9179545May 1, 1997Paper

The effect of vitamin C in high doses on plasma and biliary lipid composition in patients with cholesterol gallstones: prolongation of the nucleation time

European Journal of Clinical Investigation
U GustafssonK Einarsson

Abstract

Vitamin C deficiency in guinea pigs leads to cholesterol supersaturation of bile and formation of cholesterol gallstones. It has been suggested that there may also exist an association between vitamin C and cholesterol gallstones in man, but such a relationship has not been studied in gallstone patients. In order to study the possible effects of vitamin C on gallstone disease in humans, plasma lipid levels, hepatic cholesterol metabolism, biliary lipid composition, cholesterol saturation and nucleation time of gallbladder bile were analysed in 16 consecutive gallstone patients, who were planned for laparoscopic cholecystectomy and were treated with vitamin C (500 mg, four times a day) for 2 weeks before surgery. The plasma concentration of vitamin C increased by 42% in the treatment group. The concentrations of plasma lipids did not differ before and after vitamin C treatment; nor did the plasma levels of lathosterol and 7 alpha-hydroxy-4-cholesten-3-one, reflecting cholesterol and bile acid synthesis respectively. The relative concentrations of cholesterol, bile acids and cholesterol concentration of bile did not differ significantly between the two groups, but the relative concentration of phospholipids was slightly higher in...Continue Reading

Citations

Jan 16, 2014·Indian Journal of Clinical Biochemistry : IJCB·Shailja ChambialPraveen Sharma
Jan 1, 1974·Biochemical Pharmacology·K EinarssonK Hellström
Jun 11, 2004·Journal of the American College of Nutrition·Ada CuevasFlavio Nervi
Aug 7, 2009·European Journal of Clinical Investigation·I GrattaglianoP Portincasa
Apr 18, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL). Electronic address: easloffice@easloffice.eu
Jul 29, 2016·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Mila Pak, Glenda Lindseth
Jul 29, 2016·Korean journal of family medicine·Piero PortincasaIgnazio Grattagliano
May 31, 2017·Current Medicinal Chemistry·Agostino Di CiaulaPiero Portincasa
Aug 2, 2019·Nutrición hospitalaria·Rosa María Martínez GarcíaElena Rodríguez-Rodríguez

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