PMID: 6981692Apr 1, 1982Paper

The effect of vitamin C on the rapid induction of aortic changes in rabbits

Journal of Nutritional Science and Vitaminology
D SadavaK Downey

Abstract

Male rabbits were injected intraperitoneally for five consecutive days with one of the following: (A) 0.3 ml/kg dimethyl ethylene glycol (solvent); (B) 40 mg/kg cholesterol and 8 mg/kg ergocalciferol in solvent; (C) same regimen as B with the addition of 150 mg/kg ascorbic acid in water. Daily blood samples were taken for determination of cholesterol and triglycerides, and for lipoprotein electrophoresis. After 5 days of injections, histological sections were made of the aorta at the arch. After 5 days, group B, as compared with group A, had higher serum cholesterol (150 ng/dl vs. 50 mg/dl, p less than 0.005), higher serum triglycerides (650 mg/dl vs. 150 mg/dl, p less than 0.01), and lower high-density lipoprotein (16% vs. 35%, p less than 0.05). On autopsy, discontinuous elastic fibers and intimal damage were seen in sections of the aortas from group B, but not from group A. After 5 days, group C had control levels of cholesterol (55 mg/dl) and triglycerides (160 mg/dl), and no significant difference from the control lipoprotein profile. Injections of cholesterol alone showed a slight induction of aortic lesions and blood chemistry changes. No alterations in these parameters were induced by ergocalciferol alone. The data indi...Continue Reading

Citations

Jan 1, 1992·Critical Reviews in Food Science and Nutrition·H Hemilä

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