The effect of vitamin D supplementation on the glycemic control of pre-diabetic Qatari patients in a randomized control trial

BMC Nutrition
Mohammed Al ThaniVasiliki Leventakou

Abstract

Vitamin D deficiency is associated with indicators of pre-diabetes including, insulin resistance, β-cell dysfunction and elevated plasma glucose with controversial findings from current trials. This study aims to investigate the long-term effect of vitamin D on glucose metabolism and insulin sensitivity in pre-diabetic and highly vitamin-deficient subjects. One hundred thirty-two participants were randomized to 30,000 IU vitamin D weekly for 6 months. Participants underwent oral glucose tolerance test (OGTT) at 3-month intervals to determine the change in plasma glucose concentration at 2 h after 75 g OGTT (2hPCG). Secondary measurements included glycated hemoglobin, fasting plasma glucose and insulin, post-prandial insulin, indices of insulin sensitivity (HOMA-IR, Matsuda Index), β-cell function (HOMA-β, glucose and insulin area under the curve (AUC), disposition and insulinogenic indices), and lipid profile. A total of 57 (vitamin D) and 75 (placebo) subjects completed the study. Mean baseline serum 25(OH) D levels were 17.0 ng/ml and 14.9 ng/ml for placebo and vitamin D group, respectively. No significant differences were observed for 2hPC glucose or insulin sensitivity indices between groups. HOMA-β significantly decreased ...Continue Reading

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References

Feb 7, 2001·The American Journal of Clinical Nutrition·R ViethG D MacFarlane
Dec 25, 2002·The American Journal of Clinical Nutrition·Robert P HeaneyM Janet Barger-Lux
Mar 1, 2003·Diabetes Care·Jaana Lindström, Jaakko Tuomilehto
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Jose C FlorezDavid Altshuler
May 10, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·K G M M AlbertiJ Shaw
Jul 7, 2011·European Journal of Clinical Nutrition·J MitriA G Pittas
Feb 22, 2012·Diabetes/metabolism Research and Reviews·Sakineh Shab-BidarA'azam Gharavi
Jul 24, 2012·Current Opinion in Nephrology and Hypertension·Hector Tamez, Ravi I Thadhani
Oct 4, 2012·Diabetes Care·Mayer B DavidsonTheodore C Friedman
Apr 8, 2014·Nature Reviews. Cancer·David FeldmanBrian J Feldman
Jul 26, 2014·The Journal of Clinical Endocrinology and Metabolism·Jennifer C SeidaJeffrey A Johnson
Aug 27, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·N PoolsupN Plordplong
Apr 25, 2017·Diabetes Research and Clinical Practice·K OgurtsovaL E Makaroff
Jul 1, 2017·Journal of the American College of Cardiology·Ibhar Al Mheid, Arshed A Quyyumi
Sep 29, 2017·The Journal of Clinical Endocrinology and Metabolism·Naghmeh MirhosseiniSamantha M Kimball

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NCT02098980

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SPSS Statistics
Lotus

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