The effect of Vitamin D supplementation on hormonal and glycaemic profile of patients with PCOS: A meta-analysis of randomised trials

International Journal of Clinical Practice
Vasilios PergialiotisNikolaos Papantoniou

Abstract

Vitamin D deficiency is frequently manifested in women with polycystic ovarian syndrome (PCOS). To date, supplementation of deficient patients has not been correlated with the hormonal and metabolic status of these patients. We aimed to investigate the impact of vitamin D supplementation on the hormonal and metabolic profile of PCOS women. We searched Medline, Scopus, ClinicalTrials.gov and Cochrane Central Register databases for published randomised controlled trials. The meta-analysis was performed with the RevMan 5.3.5 software. Nine studies were included in the present meta-analysis which investigated the impact of vitamin D supplementation in 647 patients. According to our meta-analysis neither serum testosterone (MD 0.04 ng/mL, 95% CI -0.09 to 0.17) nor serum LH (MD -0.48 IU/mL, 95% CI -1.97 to 1.00) were significantly affected by vitamin D supplementation in any of the subgroup comparisons. On the contrary, serum DHEAS was significantly affected by vitamin D (MD -32.24 μg/dL, 95% CI -32.24 to -14.01) an effect which was mainly affected by the vitamin D vs placebo comparison. Vitamin D supplementation did not have an impact on fasting glucose (MD 0.42 mg/dL, 95% CI -2.75 to 3.60) or fasting insulin (MD 1.27 μU/mL, 95% CI ...Continue Reading

References

Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jun 30, 2006·Contemporary Clinical Trials·Rebecca DerSimonian, Raghu Kacker
Jul 4, 2009·Taiwanese Journal of Obstetrics & Gynecology·Batool RashidiFarid Zayerii
Jun 1, 2010·Endocrinology and Metabolism Clinics of North America·Tatiana TakiishiChantal Mathieu
Nov 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Andreea O LunguPhillip Gorden
Apr 17, 2012·Complementary Therapies in Clinical Practice·Raziah dehghani FirouzabadiSomayeh MohammadTaheri
Jul 12, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lubna PalHugh Taylor
Jan 1, 2014·Clinical Epidemiology·Susan M Sirmans, Kristen A Pate
Mar 13, 2014·The Journal of Clinical Endocrinology and Metabolism·Mohamad IraniZaher Merhi
May 23, 2014·European Journal of Endocrinology·Gerard ConwayUNKNOWN ESE PCOS Special Interest Group
Oct 21, 2015·The Journal of Clinical Endocrinology and Metabolism·Mohamad IraniReshef Tal
Dec 19, 2015·Physiological Reviews·Sylvia ChristakosGeert Carmeliet
Feb 26, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Xinyu QiJie Qiao
Mar 20, 2016·British Journal of Anaesthesia·S HeschlM Rigaud
Apr 20, 2016·Frontiers in Physiology·Samer El HayekGeorges Daoud
Dec 10, 2016·Archives of Gynecology and Obstetrics·Yunping XueLin Gu

❮ Previous
Next ❯

Citations

Nov 20, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C MarquinaB de Courten
Sep 11, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Li WangXiaofeng Yang
Nov 23, 2019·Nutrients·Johanna LummeMaarit Niinimäki
Jun 28, 2018·European Journal of Nutrition·Christian TrummerElisabeth Lerchbaum
Apr 1, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Alexandra E ButlerStephen L Atkin
May 15, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jiaqi ZhangBing He

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.