The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis.

European Journal of Pediatrics
Polyxeni NicolaidouStavros Doudounakis

Abstract

Impaired vitamin K status in cystic fibrosis (CF) has been considered as a newly emerged pathogenetic factor for reduced bone mineral density (BMD). Our aim was to evaluate the effectiveness of vitamin K supplementation in managing bone formation abnormalities in children and adolescents with CF. The statuses of vitamins K and D in relation to biochemical markers of bone metabolism and BMD were examined in 20 CF children receiving vitamin D supplements but not vitamin K supplements. Laboratory tests were carried out at the beginning of the study period and after 1 year of vitamin K supplementation (10 mg single oral dose/week) and the results were compared; the results were also compared with those of 25 healthy controls. Ten of the CF patients had BMD z-score<or=2.5 (n=5) or between -1 and -2.5 (n=5). Biochemical tests on patients before vitamin K supplementation revealed that the levels of osteoblastic activity markers, namely, bone alkaline phosphatase (BAP), serum osteocalcin (Gla-OC), serum carboxy-terminal propeptide of type I procollagen (PICP) and serum amino-terminal propeptide of type I procollagen (PINP), were significantly reduced compared with those of the controls. These patients had also lower 25-hydroxy-vitamin ...Continue Reading

References

Jan 1, 1992·The American Journal of Clinical Nutrition·B W RamseyP Pencharz
Jan 1, 1996·The Journal of Pediatrics·R C Henderson, C D Madsen
May 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·L T BekerJ A Sadowski
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·D S DonovanE Shane
Jul 22, 1998·The Journal of Pediatrics·G S BhudhikanokL K Bachrach
May 10, 2000·The Journal of Pediatrics·L A MortensenB C Marshall
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·A A IonescuD J Shale
Nov 14, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·A Zittermann
Mar 22, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R M ArisG E Lester
May 2, 2003·European Journal of Endocrinology·E LeifkeG Brabant
Jul 1, 1958·A.M.A. Journal of Diseases of Children·H SHWACHMAN, L L KULCZYCKI
Oct 29, 2003·American Journal of Respiratory and Critical Care Medicine·Robert M ArisGayle E Lester
Nov 13, 2003·Archives of Disease in Childhood·J H L van HoornP Ph Forget
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Robert M ArisTerry B White
Jan 21, 2006·The Journal of Endocrinology·John T Potts

❮ Previous
Next ❯

Citations

Jan 1, 2008·Reviews in Endocrine & Metabolic Disorders·Anuradha Viswanathan, Francisco A Sylvester
May 20, 2009·The British Journal of Nutrition·Marieke J H van SummerenCees Vermeer
Oct 21, 2006·Current Opinion in Pulmonary Medicine·Michael P Boyle
Sep 25, 2008·Current Opinion in Pulmonary Medicine·Asim Maqbool, Virginia A Stallings
Aug 27, 2010·Current Opinion in Pulmonary Medicine·Charles S Haworth
Sep 19, 2008·Journal of Pediatric Hematology/oncology·Maria AvgeriSophia Aronis
Dec 17, 2008·Journal of Paediatrics and Child Health·Konstantinos DourosStavros Doudounakis
Jul 13, 2012·Drug Design, Development and Therapy·Daina Kalnins, Michael Wilschanski
Jun 18, 2010·The American Journal of Clinical Nutrition·Kelly A DoughertyVirginia A Stallings
Mar 8, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·I Sermet-GaudelusUNKNOWN Fédération française des centres de ressource et de compétence en mucoviscidose
Jan 7, 2011·Journal of Osteoporosis·Ashwini P GoreAntine E Stenbit
Nov 28, 2013·Advances in Medical Sciences·J AmbroszkiewiczT Laskowska-Klita
Sep 29, 2011·Metabolism: Clinical and Experimental·Takeshi MatsumotoDaiki Yamamoto
Jan 15, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Rose-Marie Javier, Jacky Jacquot
Nov 26, 2009·Pediatric Clinics of North America·Suzanne H MichelMaria Mascarenhas
Aug 5, 2009·Paediatric Respiratory Reviews·Isabelle Sermet-GaudelusRobert M Aris
Nov 16, 2007·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·D S UrquhartA Jaffe
Oct 4, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J JacquotF Velard
Sep 23, 2014·Journal of Pharmaceutical and Biomedical Analysis·Ilona OlędzkaTomasz Bączek
Jul 15, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Li Li, Shawn Somerset
May 31, 2008·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Donna DruryLarry C Lands
Jan 8, 2008·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M S FewtrellA Jaffe
Apr 29, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Li Li, Shawn Somerset
Jul 15, 2015·Scientific Reports·Patrycja KrzyżanowskaJarosław Walkowiak
Apr 25, 2014·Scientific Reports·Jan K NowakJaroslaw Walkowiak
Jul 8, 2017·Journal of the American College of Nutrition·Michał KarpińskiSidney J Stohs
Apr 20, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Oranan SiwamogsathamVin Tangpricha
Aug 23, 2017·The Cochrane Database of Systematic Reviews·Vanitha A JagannathAmy I Price
Nov 5, 2008·European Journal of Pediatrics·Myriam Van WinckelStephanie Van Biervliet
Apr 7, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Daina KalninsPaul Pencharz
Apr 14, 2010·Expert Review of Respiratory Medicine·Anne Munck
Dec 19, 2013·Journal of Pediatric Gastroenterology and Nutrition·Chiara BertolasoVirginia A Stallings
Feb 22, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Adela Chirita-EmandiSyed Faisal Ahmed
Jun 5, 2020·The Cochrane Database of Systematic Reviews·Vanitha A JagannathAmy I Price
Oct 10, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Amy A SparksRobert M Aris
Jul 12, 2019·Respiratory Medicine·Gregorios HatziparasidesKonstantinos Douros
May 29, 2018·Journal of the Academy of Nutrition and Dietetics·Mary Rozga, Deepa Handu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.