The effect of white tea on serum TNF-α/NF-κB and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Sinan SaralLevent Tumkaya

Abstract

Nephrotoxicity is the most important side effect of the antineoplastic drug cisplatin, thereby restricting its use. The aim of this study was to investigate the protective effects of white tea infusions (WT) against renal damage induced by cisplatin (CP) in rats by biochemical and histopathological means. This study used 24 female Sprague Dawley rats at 12-14 weeks of age and weighing 250-300 g. Rats were divided into three groups: Control, CP and CP + WT groups. CP was injected 7 mg/kg i.p as a single dose/rat in the CP group. White tea was given at a dose of 0.5% (w/v) for 4 weeks. At the end of the experiment, blood urea nitrogen (BUN), creatinine, uric acid, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and nuclear factor kappa B (NF-κB) along with caspase-3 in the kidney were evaluated in study. BUN, creatinine, TNF-α, NF-κB and IL-6 levels of the CP group showed a statisically significant increase in comparison to the control group. TNF-α, NF-κB and IL-6 levels showed a statistically significant decrease in the CP + WT group with respect to the CP group. Caspase-3 levels in tubular epithelial cells decreased in CP + WT group compared with CP group (p = 0.02). White tea infusions reduced significantly the nephr...Continue Reading

References

Jan 1, 1993·Advances in Immunology·S AkiraT Kishimoto
Sep 6, 2000·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A SklavounouA Karameris
Oct 4, 2000·The Journal of Nutrition·C S Yang, J M Landau
Jan 3, 2001·The Journal of Clinical Investigation·A S Baldwin
Feb 24, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P E Kintzel
Dec 12, 2001·Kidney International·J DengR A Star
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Brian S Cummings, Rick G Schnellmann
Sep 17, 2002·European Journal of Pharmacology·Kunihiko SueishiRyozo Oishi
Sep 19, 2003·Seminars in Nephrology·Istvan Arany, Robert L Safirstein
May 1, 2004·Kidney & Blood Pressure Research·Heloísa D Coletta FrancescatoMaria de L P Bianchi
Jun 4, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ashok KumarBharat B Aggarwal
Jul 15, 2004·Current Opinion in Pharmacology·G Mark AndersonMark DeWitte
Aug 10, 2004·Journal of Applied Toxicology : JAT·Hüseyin OzyurtSerdar Gergerlioglu
Jan 2, 2007·Toxicology·Sevgin IşeriInci Alican
Feb 15, 2008·Kidney International·N Pabla, Z Dong
Aug 22, 2008·Kidney International·Mi Jeong SungSung Kwang Park
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Toby Lawrence
Jul 24, 2010·Journal of the American Society of Nephrology : JASN·Ana Belen SanzAlberto Ortiz
Jan 5, 2011·Cell Metabolism·Rebecca G BakerSankar Ghosh
Jul 5, 2011·Human & Experimental Toxicology·S T Ahmad, Sarwat Sultana
Nov 10, 2011·Toxins·Ronald P MillerWilliam Brian Reeves
Mar 9, 2012·Cell Biology International·Vildan B CetintasZuhal Eroglu
Jul 23, 2013·Food Chemistry·Gian Carlo TenoreEttore Novellino
Sep 2, 2014·International Journal of Pharmaceutics·Joana F FangueiroAna C Calpena
Dec 4, 2014·Obstetrics & Gynecology Science·Tae-Gyu AhnSei Jun Han
Feb 3, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mokhtar I Yousef, Hend M Hussien
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohamed M ElseweidyNahla N Younis
Mar 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gorkem AkcaAdnan Yilmaz

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Aug 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tamer I M RagabAl Shimaa Gamal Shalaby

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