The effect of Xuefu Zhuyu Decoction on in vitro endothelial progenitor cell tube formation.

Chinese Journal of Integrative Medicine
Dong GaoKe-ji Chen

Abstract

To observe the effect of Xuefu Zhuyu Decoction ()-containing serum (XFZYD-CS) on endothelial progenitor cell (EPC) tube formation in vitro. Mononuclear cells from rat bone marrow were prepared in a Ficoll density gradient centrifuge. EPCs were separated by the differential attachment method, and observed with inverted microscope for the effect of XFZYD-CS on EPC tube formation. After one day, EPCs exposed to the serum containing 5%, 10% and 15% XFZYD-CS formed typical tubes or vessel networks. The tube formation time was two days ahead of the control group and the size of most tubes in the serum groups was smaller than in the control group. XFZYD-CS could induce EPC angiogenesis and hasten tube formation, especially in capillary vessels. The study provides experimental evidence for the plausibility of Xuefu Zhuyu Decoction in the treatment of ischemic diseases.

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Citations

Jul 10, 2012·Chinese Journal of Integrative Medicine·Jun SongKe-Ji Chen
Jul 12, 2014·Chinese Journal of Integrative Medicine·Thanasekaran JayakumarJoen-rong Sheu
Mar 29, 2019·Chinese Journal of Integrative Medicine·Wei-Li ShiKe-Ji Chen
Apr 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xue XuJianxin Chen

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