The effect of zimelidine and amitriptyline on the brain concentration of some indolic and phenolic monoamines in the mouse

European Journal of Pharmacology
A V Juorio, A A Boulton

Abstract

The increase in mouse brain tryptamine accumulation rate and 5-hydroxytryptamine (5-HT) concentration and the reduction in 5-hydroxyindole acetic acid concentration observed after zimelidine administration suggest that the treatment reduces the brain tryptophan availability. Amitriptyline produced no significant changes on tryptamine, 5-HT or 5-hydroxyindole acetic acid. Also, zimelidine reduced mouse brain p-tyramine, increased m-tyramine and increased homovanillic acid. Similar effects were observed after amitriptyline administration. The experiments show that both drugs affect dopamine turnover and tyramine concentration in a similar fashion to that observed for the antipsychotic group of drugs, thus suggesting that they may have some antipsychotic effects, especially if administered at the high dose levels. In addition, it may also possess some of the undesirable effects of this group of drugs.

References

Jan 1, 1978·Journal of Neural Transmission·A Carlsson, M Lindqvist
Apr 1, 1979·Journal of Neurochemistry·J J WarshP W Chan
Oct 1, 1979·British Journal of Clinical Pharmacology·M A ReveleyA Coppen
Jan 1, 1975·Canadian Journal of Biochemistry·S R PhilipsA A Boulton
May 1, 1974·Canadian Journal of Biochemistry·S R PhilipsA A Boulton
Jun 1, 1974·Canadian Journal of Biochemistry·S R PhilipsA A Boulton
Feb 1, 1970·British Journal of Pharmacology·R O'KeeffeM Vogt
Nov 1, 1966·Journal of Neurochemistry·E Giacalone, L Valzelli
Jun 1, 1982·The Journal of Pharmacy and Pharmacology·P C Waldmeier
Nov 1, 1980·European Journal of Clinical Pharmacology·L BertilssonB Siwers
Jan 1, 1983·Journal of Neuroscience Research·L E DyckA A Boulton
Feb 15, 1983·Experientia·A A Boulton, A V Juorio
Apr 1, 1965·British Journal of Pharmacology and Chemotherapy·R LAVERTY, D F SHARMAN

Citations

Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M M Fathi Fahim el-S
Feb 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·C Barbui, M Hotopf
Mar 1, 1996·Health Care for Women International·M YuN E Reame
Jun 16, 2010·Journal of Clinical Pharmacology·Yeong-Liang LinMei-Fen Kung
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Claudia LeuchtStefan Leucht
Jul 20, 2007·The Cochrane Database of Systematic Reviews·G GuaianaM Hotopf
Jan 16, 2009·Pharmacoepidemiology and Drug Safety·Yeong-Liang Lin, Mei-Fen Kung
Jan 1, 1989·Psychological Medicine. Monograph Supplement·S J WarringtonM Lader

Related Concepts

Damilen
Metazoa
Brain
Catecholamines
Intropin
Homovanillic Acid
Hydroxyindoleacetic Acid
Triptans
Tyramine
Zelmid

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