PMID: 9434661Jan 22, 1998Paper

The effect of zinc and vitamin A supplementation on immune response in an older population

Journal of the American Geriatrics Society
C FortesC A Perucci

Abstract

To determine if either supplemental vitamin A, zinc, or both increases cell-mediated immune response in an older population. A double-blind, randomized, controlled trial of supplementation with vitamin A and zinc. Casa Di Riposo Roma III, a public home for older people in Rome, Italy. The health and nutritional status of 178 residents were evaluated. One hundred thirty-six residents agreed to participate in the trial and were randomized into four treatment groups, and 118 of these residents completed the trial. The four treatments consisted of: (1) Vitamin A (800 micrograms retinol palmitate); (2) Zinc (25 mg as zinc sulfate); (3) Vitamin A and Zinc (800 micrograms retinol palmitate and 25 mg as zinc sulfate); (4) Placebo capsules containing starch. Immune tests-counts of leucocytes, lymphocytes, T-cell subsets, and lymphocyte proliferative response to mitogens-were measured before and after supplementation. Zinc increased the number of CD4 + DR + T-cells (P = .016) and cytotoxic T-lymphocytes (P = .005). Subjects treated with vitamin A experienced a reduction in the number of CD3 + T-cells (P = .012) and CD4 + T-cells (P = .012). These data indicate that zinc supplementation improved cell-mediated immune response, whereas vita...Continue Reading

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Citations

Nov 26, 2008·Journal of the American Dietetic Association·Laura WardwellJeffrey Woods
Apr 24, 2008·The Science of the Total Environment·Philip G Reeves, Rufus L Chaney
Dec 23, 2003·Journal of the American Geriatrics Society·Bobbi Langkamp-HenkenSteven M Wood
Nov 15, 2011·Molecular Nutrition & Food Research·Carmen P Wong, Emily Ho
May 6, 2004·Journal of the American Dietetic Association·Deborah E Wildish
Oct 13, 2006·Experimental Gerontology·Eugenio MocchegianiMarco Malavolta
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