The effect of zinc supplementation during pregnancy on immune response to Hib and BCG vaccines in Bangladesh

Journal of Tropical Pediatrics
Saskia J M OsendarpM Santosham

Abstract

An essential role for zinc in development of the fetal immune system has been documented. However, the effect of antenatal zinc supplementation on infants' postnatal immune response to vaccinations is unknown. The objective of this study was to evaluate the effect of zinc supplementation during pregnancy on immune response to the Bacillus Calmette-Guerin (BCG) vaccine and the Haemophilus influenzae type b (Hib) component of the combined diphtheria, tetanus toxoid and pertussis (DTP)-Haemophilus influenzae type-b (Hib)- conjugate vaccine in poor Bangladeshi infants. We immunized 405 infants whose mothers were supplemented daily with 30 mg elemental zinc or placebo beginning at 12-16 weeks gestation with the standard BCG vaccine at birth. A subcohort of 203 infants were in addition immunized at 1-month intervals with three doses of DTP-Hib vaccine starting at 9 weeks of age. The delayed hypersensitivity (PPD) skin test was performed in 345 infants at 24 weeks of age. Hib polysaccharide (PRP) antibodies were assessed for 91 infants at 4 and 24 weeks of age. In infants born with low birth weight (LBW) a lower proportion of negative responses to PPD skin test were observed in the zinc (66.2%) compared to placebo (78.5%) group (p = 0...Continue Reading

Citations

Feb 15, 2012·Advances in Nutrition·Amanda C Palmer
Nov 13, 2009·Nutrition Reviews·Susanna Cunningham-RundlesJeffrey M Perlman
Jul 26, 2015·European Journal of Nutrition·Shaikh Meshbahuddin AhmadBo L Lönnerdal
Jun 24, 2011·The Journal of Nutrition·Mohammad T K SharkarRubhana Raqib
Apr 3, 2015·The Journal of Nutrition·Daniel J RaitenUNKNOWN INSPIRE Consultative Group
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