The effect on early renal function of various dynamic preservation strategies in a preclinical pig ischemia-reperfusion autotransplant model

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Tom DariusMichel Mourad

Abstract

The aims of this study were to determine the most optimal timing to start machine perfusion during kidney preservation to improve early graft function and to evaluate the impact of temperature and oxygen supply during machine perfusion in a porcine ischemia-reperfusion autotransplant model. The left kidney of an approximately 40-kg female Belgian Landrace pig was exposed to 30 minutes of warm ischemia via vascular clamping and randomized to 1 of 6 study groups: (1) 22-hour static cold storage (SCS) (n = 6), (2) 22-hour hypothermic machine perfusion (HMP) (n = 6), (3) 22-hour oxygenated HMP (n = 7), (4) 20-hour HMP plus 2-hour normothermic perfusion (NP) (n = 6), (5) 20-hour SCS plus 2-hour oxygenated HMP (n = 7), and (6) 20-hour SCS plus 2-hour NP (n = 6). Graft recovery measured by serum creatinine level was significantly faster for continuous HMP preservation strategies compared with SCS alone and for all end-ischemic strategies. The active oxygenated 22-hour HMP group demonstrated a significantly faster recovery from early graft function compared with the 22-hour nonactive oxygenated HMP group. Active oxygenation was also found to be an important modulator of a faster increase in renal flow during HMP preservation. Continuou...Continue Reading

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Citations

Jun 6, 2019·Expert Opinion on Investigational Drugs·Raphael ThuillierThierry Hauet
Feb 6, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Tom DariusMichel Mourad
Jan 24, 2020·Annals of Plastic Surgery·Ryan M DickeyThomas M Suszynski
Mar 27, 2020·Journal of Clinical Medicine·Julie De Beule, Ina Jochmans
Sep 9, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Tegwen R ElliottSarah A Hosgood
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Jan 1, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stine LohmannBente Jespersen
Aug 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Rianne SchutterRonald J H Borra
May 14, 2021·Transplantation·Sarah A HosgoodMichael L Nicholson

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