The effect on health of alternate day calorie restriction: eating less and more than needed on alternate days prolongs life

Medical Hypotheses
James B JohnsonSujit John

Abstract

Restricting caloric intake to 60-70% of normal adult weight maintenance requirement prolongs lifespan 30-50% and confers near perfect health across a broad range of species. Every other day feeding produces similar effects in rodents, and profound beneficial physiologic changes have been demonstrated in the absence of weight loss in ob/ob mice. Since May 2003 we have experimented with alternate day calorie restriction, one day consuming 20-50% of estimated daily caloric requirement and the next day ad lib eating, and have observed health benefits starting in as little as two weeks, in insulin resistance, asthma, seasonal allergies, infectious diseases of viral, bacterial and fungal origin (viral URI, recurrent bacterial tonsillitis, chronic sinusitis, periodontal disease), autoimmune disorder (rheumatoid arthritis), osteoarthritis, symptoms due to CNS inflammatory lesions (Tourette's, Meniere's) cardiac arrhythmias (PVCs, atrial fibrillation), menopause related hot flashes. We hypothesize that other many conditions would be delayed, prevented or improved, including Alzheimer's, Parkinson's, multiple sclerosis, brain injury due to thrombotic stroke atherosclerosis, NIDDM, congestive heart failure. Our hypothesis is supported by ...Continue Reading

References

Mar 21, 1998·BMJ : British Medical Journal·S FrankelG Davey Smith
Jun 29, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S B RobertsS Shapses
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·R Michael AnsonMark P Mattson

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Citations

Nov 17, 2011·Journal of Physiology and Biochemistry·María Antonieta Suárez-SoutoRafael Campos-Rodríguez
Feb 3, 2009·Journal of Toxicology and Environmental Health. Part a·Mohammed AzabKarem Alzoubi
Sep 14, 2011·Experimental & Translational Stroke Medicine·Silvia ManzaneroThiruma V Arumugam
Mar 19, 2013·Journal of Diabetes and Metabolic Disorders·Samira Eshghinia, Fatemeh Mohammadzadeh
May 21, 2010·The Journal of Nutrition·Roger B McDonald, Jon J Ramsey
Apr 16, 2013·Revista da Associação Médica Brasileira·Fernanda Reis de AzevedoBruno Caramelli
Mar 17, 2010·Medical Hypotheses·David Lovell-SmithStephen Buetow
Oct 11, 2008·Brain Research Reviews·Marwan MaaloufMark P Mattson
Sep 24, 2015·Nutrition Research Reviews·Sibylle NikolaiGerald Rimbach
Mar 13, 2014·Scandinavian Journal of Immunology·M Godínez-VictoriaM E Drago-Serrano
Dec 30, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Johnstone
Aug 15, 2006·Journal of the American College of Cardiology·James B JohnsonSujit John
Jan 16, 2007·Current Opinion in Lipidology·Christopher A Jolly
Jun 16, 2007·Gerontology·Stephen R Spindler, Patricia L Mote
Apr 14, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Laura V DugganHilary P Grocott
Mar 30, 2018·Frontiers in Molecular Neuroscience·Zhuoran YinBart J L Eggen
Feb 9, 2021·Advances in Nutrition·Tunay KöktenLaurent Peyrin-Biroulet
Jun 3, 2021·Nutrients·Alda AttinàLaura Di Renzo

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