The effect on total renal and tubular function and plasma renin of a moderate isotonic saline load in rats anesthetized with amytal and inactin.

Acta Physiologica Scandinavica
P P LeyssacS L Skinner

Abstract

The renal effects of i.v. saline loading equal to 1% body weight (b.wt.) were studied in 2 groups of rats: group I was anesthetized with Amytal (15 mg/100 g b.wt. plus supplementary doses), group II with Inactin (12.5-15.0 mg/100 g b.wt.). In group I the saline load caused an increase in urine flow (+92%), solute excretion (+67%), inulin clearance (CIN) (+24%), PAH clearance (+31%) and absolute proximal reabsorption rate (+27%). Proximal fractional reabsorption and filtration fraction (FF) remained unchanged, while plasma oncotic pressure (COP) decreased by 10%. Plasma renin fell and there was an inverse relationship between renin concentration and proximal reabsorption rate. In group II urine flow and solute excretion increased after saline (+85% and 110%, respectively); CIN and absolute proximal reabsorption rate was lower than in group I and failed to increase after saline. Proximal fractional reabsorption was also lower and decreased after saline. COP as well as renin decreased as in group I, but no relationship between renin concentration and proximal reabsorption rate could be demonstrated. The data indicate that Inactin depresses both resting proximal tubular reabsorptive capacity and the tubular response to a physiologi...Continue Reading

References

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Citations

Apr 1, 1990·Pflügers Archiv : European journal of physiology·D G ShirleyS J Walter
Jan 1, 1989·Pflügers Archiv : European journal of physiology·P P Leyssac, N H Holstein-Rathlou
Feb 22, 1978·Pflügers Archiv : European journal of physiology·T F KnightE J Weinman
Mar 1, 1983·Acta Physiologica Scandinavica·P P Leyssac, L Baumbach
Dec 1, 1995·Acta Physiologica Scandinavica·F M KarlsenP P Leyssac
Nov 26, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·O V SosnovtsevaN-H Holstein-Rathlou
Aug 1, 1981·European Journal of Clinical Investigation·H SporerP Deetjen

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