The effectiveness of a fixed-dose combination pour-on formulation of 1.25% fipronil and 2.5% fluazuron against economically important ectoparasites and associated pharmacokinetics in cattle

Parasitology International
Welber Daniel Zanetti LopesRafael Bazaglia Sonada

Abstract

The present work consisted of eight studies to evaluate the ectoparasiticidal spectrum and determine the pharmacokinetic parameters of a pour-on combination of fipronil 1.25mg/kg+fluazuron 2.5mg/kg for cattle against Rhipicephalus microplus, Haematobia irritans and the larvae of Dermatobia hominis and Cochliomyia hominivorax. The analysis fipronil and fluazuron were performed by liquid chromatography using a mass detector for the detection and quantification of analytes (LC-MS/MS). Additionally, in two of these studies, the animals were artificially infested with R. microplus ticks (stall tests), and the efficacy of this formulation was compared with that of two other standalone pour-on formulations of fipronil 1.0mg/kg and fluazuron 2.5mg/kg. In the two stall studies, 28 calves were artificially infested with 5000 R. microplus (different strains), and daily collections of all of the engorged female ticks that detached from each calf were performed until 60 and 100days post-treatment (dpt). For the R. microplus field trials, 20 bovines were selected by counting the semi-engorged females, and the therapeutic and residual efficacy was evaluated by taking tick counts at 3, 7, 14, 21, 28, 35, 42, 49 and 56dpt. Forty bovines that we...Continue Reading

References

Dec 27, 2005·Veterinary Parasitology·P A HoldsworthUNKNOWN World Association for the Advancement of Veterinary Parasitology
Jan 16, 2007·Journal of Veterinary Pharmacology and Therapeutics·F A BorgesA J Costa
Apr 27, 2012·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Felix David GuerreroJoão Ricardo Martins
May 24, 2014·Preventive Veterinary Medicine·Welber Daniel Zanetti LopesAlvimar José da Costa
Jul 24, 2014·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Laerte GrisiHumberto Silva Villela
Dec 4, 2014·Preventive Veterinary Medicine·WillianGiquelin MacielAlvimar José da Costa
Jan 13, 2015·Veterinary Parasitology·Breno Cayeiro CruzGilson Pereira De Oliveira
Apr 15, 2015·Veterinary Parasitology·E Castro JanerT T S Schumaker
Jul 30, 2015·Veterinary Parasitology·Carlos LanusseLuis Alvarez
Sep 24, 2015·Veterinary Record Open·Heloisa Cristina SilvaAlvimar José da Costa

❮ Previous
Next ❯

Citations

May 2, 2019·Parasite : Journal De La Société Française De Parasitologie·Pablo JunqueraAlicia Macdonald
Sep 5, 2019·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Livio Martins Costa-JúniorAntonio Thadeu Medeiros Barros
Dec 6, 2018·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Breno Cayeiro CruzWelber Daniel Zanetti Lopes
May 14, 2021·Ticks and Tick-borne Diseases·João Eduardo NicarettaWelber Daniel Zanetti Lopes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.