The effectiveness of a traditional Persian medicine preparation in the treatment of chronic cough: A randomized, double-blinded, placebo-controlled clinical trial

Complementary Therapies in Medicine
Hajar GhaemiHossein Niknahad

Abstract

The roots and rhizomes of licorice (Glycyrrhiza glabra L.) are used in traditional Persian medicine for the treatment of numerous diseases. A chronic cough is a non-specific reaction to irritation anywhere in the respiratory system. It usually lasts for more than eight weeks. The current study aimed to evaluate the effect of a modified traditional Persian medicine preparation, licorice pastille, in healing a chronic cough. Through a randomized, double-blinded, placebo-controlled clinical trial was performed in a respiratory disease clinic in Shiraz, Iran; between October 2016 and December 2017. Seventy participants with a chronic cough took part in the trial. The outcome measures were as the daily cough scores (the score being logged via patient symptoms, diary, and the visual analogue scale) and the quality of life measure of chronic cough according to the Leicester Cough Questionnaire. At baseline, there were no significant differences in the demographic or clinical (cough score) characteristics between the two groups. There was complete adherence to protocol in both groups but, the drop-out rate was 4 patients in the placebo and 6 ones in the intervention groups. The results at the end of the trial (Week 2) and follow-up (We...Continue Reading

References

Jan 10, 2008·Journal of Ethnopharmacology·Vivek K GuptaSuman P S Khanuja
Feb 19, 2011·International Journal of Biological Macromolecules·Sudipta SahaBimalendu Ray
Mar 10, 2015·Allergy, Asthma & Immunology Research·Jae Woo KwonUNKNOWN Work Group for Chronic Cough, the Korean Academy of Asthma, Allergy and Clinical Immunology
May 27, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Hossein Karegar-BorziRoja Rahimi
Sep 22, 2016·Pharmaceutical Biology·Rui YangYing Liu
Nov 12, 2016·BMC Complementary and Alternative Medicine·Yu-Chin LinChi-Rei Wu
Dec 12, 2017·Bioorganic & Medicinal Chemistry·Yi KuangMin Ye

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